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Showing 1–3 of 3 results
Advanced filters: Author: Maria Zacharopoulou Clear advanced filters

  • In Parkinson’s disease (PD) the monomeric protein alpha-synuclein (aSyn) misfolds and aggregates into insoluble fibrils. Here the authors use NMR measurements and hydrogen–deuterium exchange mass spectrometry and find that the more solvent exposed the N-terminus of aSyn is, the more aggregation prone its conformation becomes, and further show how PD mutations and post translational modifications influence the extent of the N-terminus solvent exposure.

    • Amberley D. Stephens
    • Maria Zacharopoulou
    • Gabriele S. Kaminski Schierle
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • Alpha-synuclein is associated with neuronal dysfunction in Parkinson’s disease. This study shows that alpha-synuclein interacts with neuronal synaptic vesicles in a calcium-dependent fashion, and this interaction is important for synaptic vesicle clustering.

    • Janin Lautenschläger
    • Amberley D. Stephens
    • Gabriele S. Kaminski Schierle
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13