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Showing 1–3 of 3 results
Advanced filters: Author: Maria-Isabel Yuseff Clear advanced filters

  • Cell polarity is marked by re-orientation of the centrosome, but the mechanisms governing centrosome polarization are poorly understood. Here Obino et al. show that in lymphocytes centrosome-associated Arp2/3 nucleates actin that tethers the centrosome to the nucleus; activation depletes Arp2/3 from the centrosome and frees it from the nucleus.

    • Dorian Obino
    • Francesca Farina
    • Ana-Maria Lennon-Duménil
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14

  • In this Review, the authors discuss the molecular mechanisms that enable B cells to internalize, process and present antigens on MHC class II molecules to CD4+T cells. They focus on the importance of cytoskeletal rearrangements and the establishment of polarity in B cells for these processes.

    • Maria-Isabel Yuseff
    • Paolo Pierobon
    • Ana-Maria Lennon-Duménil
    Reviews
    Nature Reviews Immunology
    Volume: 13, P: 475-486