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Showing 1–3 of 3 results
Advanced filters: Author: Maria-Vittoria Mazzuoli Clear advanced filters

  • CRISPR-Cas9 is an adaptive immune system that protects bacteria against invading DNA. Here, the authors show that the master virulence regulator CovR controls the CRISPR-Cas9 system in Streptococcus agalactiae, allowing transient increases in Cas9 off-target activity to overcome escape mutations in the target DNA, boost immune memory recall, and promote new memory acquisition.

    • Adeline Pastuszka
    • Maria-Vittoria Mazzuoli
    • Arnaud Firon
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Genome engineering in bacteria remains a complex multistep process. Here, the authors developed make-or-break Prime Editing, a precise method for genetic modification in Streptococcus pneumoniae that enables high-throughput and scalable genome editing.

    • Monica Rengifo-Gonzalez
    • Maria-Vittoria Mazzuoli
    • Jan-Willem Veening
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Bacterial two-component systems (TCSs) consist of a sensor histidine kinase (HK) and a response regulator that modulate gene expression. Here, the authors generate phosphatase-deficient HK mutants, with constitutive TCS activation, to characterise the regulatory networks of 14 TCSs in the human pathogen Streptococcus agalactiae.

    • Cosme Claverie
    • Francesco Coppolino
    • Arnaud Firon
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12