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Showing 1–2 of 2 results
Advanced filters: Author: Marian Bataclan Clear advanced filters

  • The m6A mRNA modification is essential for immune cell function. Here, the Monticelli lab optimized methods of gene editing by CRISPR-Cas9 in mast cells and revealed how the m6A machinery is required to sustain proliferation and to limit the production of inflammatory cytokines by these cells.

    • Cristina Leoni
    • Marian Bataclan
    • Silvia Monticelli
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Heissmeyer and colleagues show that TCR stimulation-induced cell death is controlled by N6-methyladenosine (m6A) modification of Orai1 and Ripk1 mRNAs. m6A is deposited by a ‘writer’ complex of Wtap and the N6-methyltransferase and bound by the ‘reader’ protein Ythdf2. T cells lacking Wtap exhibit enhanced Ca2+ entry in response to TCR ligation and decreased survival due to activation-induced cell death.

    • Taku Ito-Kureha
    • Cristina Leoni
    • Vigo Heissmeyer
    Research
    Nature Immunology
    Volume: 23, P: 1208-1221