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TYK2 mediates neuroinflammation in Alzheimer’s disease brains with TDP-43 pathology

Cytoplasmic dsRNA co-localizes with TDP-43 inclusions in Alzheimer’s disease brain cells, driving neurotoxic interferon signaling. JAK inhibitors and TYK2 blockade rescue this toxicity, identifying TYK2 as a target for TDP-43-linked AD and ALS.

Laura E. König
Steve Rodriguez
Mark W. Albers
ResearchOpen Access14 Mar 2026
Nature Communications

P: 1-19
Radiocarbon dating of prehistoric rock paintings by selective oxidation of organic carbon

Jon Russ
Marian Hyman
Marvin W. Rowe
Research27 Dec 1990
Nature

Volume: 348, P: 710-711
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
Outcome of ovarian cancer after breast cancer in BRCA1 and BRCA2 mutation carriers

Leendert H Zaaijer
Helena C van Doorn
Mieke Kriege
ResearchOpen Access18 Oct 2016
British Journal of Cancer

Volume: 115, P: 1174-1178

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TYK2 mediates neuroinflammation in Alzheimer’s disease brains with TDP-43 pathology

Radiocarbon dating of prehistoric rock paintings by selective oxidation of organic carbon

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Outcome of ovarian cancer after breast cancer in BRCA1 and BRCA2 mutation carriers

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