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Showing 1–4 of 4 results

Advanced filters: Author: Marianna Agudelo Clear advanced filters

Convergent antibody responses to SARS-CoV-2 in convalescent individuals

Although rare, antibodies against the receptor-binding domain of SARS-CoV-2 that showed potent antiviral activity were obtained from all tested convalescent individuals, suggesting that a vaccine designed to elicit such antibodies could be broadly effective.

Davide F. Robbiani
Christian Gaebler
Michel C. Nussenzweig
Research18 Jun 2020
Nature

Volume: 584, P: 437-442
Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies

Emerging SARS-CoV-2 mutants may escape neutralization by antibodies. Here, the authors use deep mutational scanning to identify mutations in the RBD that escape human monoclonal antibodies or convalescent plasmas.

Allison J. Greaney
Tyler N. Starr
Jesse D. Bloom
ResearchOpen Access07 Jul 2021
Nature Communications

Volume: 12, P: 1-14
Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination

Individual memory antibodies selected over time by natural infection with SARS-CoV-2 have greater potency and breadth than antibodies elicited by vaccination, whereas the overall neutralizing potency of plasma is greater following vaccination.

Alice Cho
Frauke Muecksch
Michel C. Nussenzweig
ResearchOpen Access07 Oct 2021
Nature

Volume: 600, P: 517-522
Monitoring T cell–dendritic cell interactions in vivo by intercellular enzymatic labelling

Interactions between receptors and ligands on immune cells are visualized in vivo and in vitro using an enzyme-tagged ligand that, when cells interact, leaves behind a detectable label on the receptor-expressing cell.

Giulia Pasqual
Aleksey Chudnovskiy
Gabriel D. Victora
Research17 Jan 2018
Nature

Volume: 553, P: 496-500