Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–9 of 9 results
Advanced filters: Author: Marianne Koritzinsky Clear advanced filters

  • Distinguishing the drivers of metastasis versus those of the primary tumour in breast cancer remains challenging. Here, the authors explore primary-only, metastatic-only, and shared drivers in breast cancer using mammary-specific transposon mutagenesis screens, which leads to potential therapeutic targets to prevent metastasis.

    • Zhe Jiang
    • YoungJun Ju
    • Eldad Zacksenhaus
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-22

  • Reduced expression of DICER—responsible for the processing of microRNA precursors—was previously linked to poor clinical outcomes in cancer patients. Here, the authors uncover an epigenetic mechanism by which hypoxia suppresses DICER expression and deregulates the miR-200-Zeb1 circuit in breast cancer to promote the tumour phenotype.

    • Twan van den Beucken
    • Elizabeth Koch
    • Bradly G. Wouters
    Research
    Nature Communications
    Volume: 5, P: 1-13

  • Cancer metabolism adapts the metabolic network of its cell of origin. Mahendralingam et al. find that lineage-rooted metabolic identities of normal mammary cells reflect breast cancer subtype metabolism.

    • Mathepan Jeya Mahendralingam
    • Hyeyeon Kim
    • Rama Khokha
    Research
    Nature Metabolism
    Volume: 3, P: 665-681

  • Neuroendocrine prostate cancer (NEPC) is characterized by loss of androgen receptor (AR) signaling during neuroendocrine transdifferentiation, resulting in resistance to AR-targeted therapy. Here they report ONECUT2 to drive NEPC tumorigenesis via regulation of hypoxia signaling and tumor hypoxia, and find hypoxia directed therapy to be effective in NEPC.

    • Haiyang Guo
    • Xinpei Ci
    • Housheng Hansen He
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Analysis of matched pairs of head and neck squamous cell carcinoma (HNSCC) lines from primary and metastatic sites identifies differential expression of Notch3 components, and suppression of Notch3 improves survival in mouse models of metastatic HNSCC.

    • Maria Kondratyev
    • Aleksandra Pesic
    • Bradly G. Wouters
    ResearchOpen Access
    Communications Biology
    Volume: 6, P: 1-17

  • Responses to hypoxia are orchestrated not only through activation of the hypoxia–inducible factor family of transcription factors (HIFs), but also through HIF–independent signalling pathways. How are these pathways integrated?

    • Bradly G. Wouters
    • Marianne Koritzinsky
    Reviews
    Nature Reviews Cancer
    Volume: 8, P: 851-864

  • Mona Shehata et al. study the effects of metformin, an antidiabetic drug with potential as a breast cancer treatment, in the normal mouse mammary gland. They find that metformin targets hormone receptor positive (HR+) luminal cells and decreases the progenitor capacity of these cells when administered at clinically relevant doses.

    • Mona Shehata
    • Hyeyeon Kim
    • Rama Khokha
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-11