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Author Correction: Slc12a8 is a nicotinamide mononucleotide transporter

Alessia Grozio
Kathryn F. Mills
Shin-ichiro Imai
Amendments and Corrections12 Jul 2019
Nature Metabolism

Volume: 1, P: 743
NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

Raising cellular levels of the metabolic cofactor NAD⁺ reverses key indicators of aging. Here, Ratajczak et al. show that cellular levels of NAD⁺ depend on the extracellular catalytic activity of NRK1, which processes two NAD⁺precursors, nicotinamide mononucleotide and nicotinamide riboside, in mice.

Joanna Ratajczak
Magali Joffraud
Carles Cantó
ResearchOpen Access11 Oct 2016
Nature Communications

Volume: 7, P: 1-12
Author Correction: Discovery of fungal surface NADases predominantly present in pathogenic species

Øyvind Strømland
Juha P. Kallio
Mathias Ziegler
Amendments and CorrectionsOpen Access25 Mar 2021
Nature Communications

Volume: 12, P: 1
Reply to: Absence of evidence that Slc12a8 encodes a nicotinamide mononucleotide transporter

Alessia Grozio
Kathryn Mills
Shin-ichiro Imai
Research12 Jul 2019
Nature Metabolism

Volume: 1, P: 662-665
Genetic inhibition of CARD9 accelerates the development of atherosclerosis in mice through CD36 dependent-defective autophagy

Previous studies suggested a role for CARD9 pathway in atherosclerosis but the underlying mechanisms remain poorly understood. Here, the authors show that the pro-atherogenic effects of Card9 deficiency are mediated by CD36-dependent defective autophagy that can be reversed by rapamycin and metformin.

Yujiao Zhang
Marie Vandestienne
Hafid Ait-Oufella
ResearchOpen Access01 Aug 2023
Nature Communications

Volume: 14, P: 1-17
Subcellular NAD⁺ pools are interconnected and buffered by mitochondrial NAD⁺

By increasing NAD⁺ consumption in various organelles, mitochondria are revealed to act as buffers that help maintain subcellular NAD⁺ levels. At the same time, cells are found to be particularly sensitive to a decline in NAD⁺ levels originating from mitochondria themselves.

Lena E. Høyland
Magali R. VanLinden
Mathias Ziegler
Research13 Dec 2024
Nature Metabolism

Volume: 6, P: 2319-2337
BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities

Nicotinamide riboside (NR) is a NAD + precursor exhibiting beneficial effects against aging. Here the authors demonstrate that orally administered NR increases NAD + levels in a diphasic manner and that bone marrow stromal cell antigen 1 plays a crucial role for NAD + synthesis from NR.

Keisuke Yaku
Sailesh Palikhe
Takashi Nakagawa
ResearchOpen Access19 Nov 2021
Nature Communications

Volume: 12, P: 1-17
Trigonelline is an NAD⁺ precursor that improves muscle function during ageing and is reduced in human sarcopenia

Trigonelline is identified as a human metabolite that can be used for NAD⁺ synthesis and is shown to improve muscle function in aged worms and mice.

Mathieu Membrez
Eugenia Migliavacca
Jerome N. Feige
ResearchOpen Access19 Mar 2024
Nature Metabolism

Volume: 6, P: 433-447
SLC25A51 is a mammalian mitochondrial NAD⁺ transporter

SLC25A51 is identified as a transporter of intact NAD⁺ into mammalian mitochondria and is required to maintain the mitochondrial NAD⁺ pool and respiratory function.

Timothy S. Luongo
Jared M. Eller
Joseph A. Baur
Research09 Sept 2020
Nature

Volume: 588, P: 174-179
Slc12a8 is a nicotinamide mononucleotide transporter

Nicotinamide mononucleotide (NMN) is a biosynthetic precursor of NAD⁺, but how NMN is taken up into cells has not been entirely clear. Here the authors discover a specific NMN transporter, encoded by the Slc12a8 gene, which regulates NMN uptake and cellular NAD⁺ levels in vitro and in the mouse intestine in vivo.

Alessia Grozio
Kathryn F. Mills
Shin-ichiro Imai
Research07 Jan 2019
Nature Metabolism

Volume: 1, P: 47-57
Macrophage de novo NAD⁺ synthesis specifies immune function in aging and inflammation

Macrophages alter their metabolism in response to infection. The authors show that resting macrophages generate nicotinamide adenine dinucleotide via de novo synthesis, but activated and aged cells suppress the rate-limiting enzyme quinolinate phosphoribosyltransferase to regulate mitochondrial and immunological functions.

Paras S. Minhas
Ling Liu
Katrin I. Andreasson
Research26 Nov 2018
Nature Immunology

Volume: 20, P: 50-63
Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

NAD⁺ is an important coenzyme that mediates cellular metabolism and defends against stresses due to age and overnutrition. Here the authors demonstrate unique bioavailability of the NAD⁺ precursor vitamin nicotinamide riboside (NR) in mice and humans, and show that NR safely elevates human NAD⁺.

Samuel A. J. Trammell
Mark S. Schmidt
Charles Brenner
ResearchOpen Access10 Oct 2016
Nature Communications

Volume: 7, P: 1-14
Discovery of fungal surface NADases predominantly present in pathogenic species

Some bacterial pathogens release NADase enzymes into the host cell that deplete the host’s NAD⁺ pool, thereby causing rapid cell death. Here, Strømland et al. identify NADases on the surface of fungal spores, and show that the enzymes display unique biochemical and structural properties.

Øyvind Strømland
Juha P. Kallio
Mathias Ziegler
ResearchOpen Access12 Mar 2021
Nature Communications

Volume: 12, P: 1-13
A metabolomic endotype of bioenergetic dysfunction predicts mortality in critically ill patients with acute respiratory failure

Raymond J. Langley
Marie E. Migaud
Peter E. Morris
ResearchOpen Access18 May 2021
Scientific Reports

Volume: 11, P: 1-12
Regulation of and challenges in targeting NAD⁺ metabolism

Nicotinamide adenine dinucleotide (NAD⁺) has essential roles in metabolism and can be readily supplemented, potentially to benefit human health. This Review discusses recent insights into the roles of the microbiome and cellular compartments in regulating NAD⁺ metabolism, and the promise and pitfalls of NAD⁺ supplementation.

Marie E. Migaud
Mathias Ziegler
Joseph A. Baur
Reviews18 Jul 2024
Nature Reviews Molecular Cell Biology

Volume: 25, P: 822-840
Targeting the autophagy-NAD axis protects against cell death in Niemann-Pick type C1 disease models

Tetsushi Kataura
Lucia Sedlackova
Viktor I. Korolchuk
ResearchOpen Access31 May 2024
Cell Death & Disease

Volume: 15, P: 1-13
Constitutive and Acquired Serotonin Deficiency Alters Memory and Hippocampal Synaptic Plasticity

Sebastian P Fernandez
Aude Muzerelle
Patricia Gaspar
Research27 Jul 2016
Neuropsychopharmacology

Volume: 42, P: 512-523
A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells

Using in silico modeling, Li et al. identify a selective inhibitor for aldehyde dehydrogenase isoform ALDH1A3, which is highly expressed in mesenchymal glioma stem cells and therefore a potential drug target. They solve the structure of the ALDH1A3/MCI-INI-3 inhibitor complex and find that the inhibitor is as efficient as ALDH1A3 depletion in preventing retinoic acid biosynthesis.

Jianfeng Li
Silvia Garavaglia
Robert W. Sobol
ResearchOpen Access21 Dec 2021
Communications Biology

Volume: 4, P: 1-16
Extracellular NAD⁺ enhances PARP-dependent DNA repair capacity independently of CD73 activity

Anna Wilk
Faisal Hayat
Robert W. Sobol
ResearchOpen Access20 Jan 2020
Scientific Reports

Volume: 10, P: 1-21
High level of soluble programmed cell death ligand 1 in blood impacts overall survival in aggressive diffuse large B-Cell lymphoma: results from a French multicenter clinical trial

D Rossille
M Gressier
P Godemer
Research15 Apr 2014
Leukemia

Volume: 28, P: 2367-2375

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