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Showing 1–3 of 3 results
Advanced filters: Author: Marie-Astrid Hoogerwerf Clear advanced filters

  • Hookworm infection remains a threat to public health where economic factors restrict treatment and lack of effective vaccination have limited successful therapeutic control which results in reinfection in endemic areas. Here the authors use a controlled human hookworm infection model and use high dimensional single cell profiling to show that plasmacytoid dendritic cells and regulatory T cells profiles that resemble those seen during natural infections in endemic areas.

    • Mikhael D. Manurung
    • Friederike Sonnet
    • Maria Yazdanbakhsh
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • In the current COVID-19 pandemic, many researchers are applying to research ethics committees for deferred-consent procedures for protocols that aim either to test treatments or to obtain tissue or samples from research participants. However, the deferred-consent procedure has not been developed for pandemics. In this Comment, we interpret existing guidance documents and argue when and under which conditions deferred consent can be considered ethically acceptable in a pandemic.

    • Rieke van der Graaf
    • Marie-Astrid Hoogerwerf
    • Martine C. de Vries
    Comments & Opinion
    Nature Medicine
    Volume: 26, P: 1328-1330