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Showing 1–10 of 10 results
Advanced filters: Author: Marie-Paule Strub Clear advanced filters

  • Cryo-electron tomography requires thin samples. Few cell-thinning techniques have been standardized. Here, the authors provide and validate a method to prepare, label, and image proteins at mammalian cell plasma membranes for sub-nanometer structural analysis.

    • Willy W. Sun
    • Dennis J. Michalak
    • Justin W. Taraska
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Cryo-electron microscopy structures of OPA1, mutations of which are associated with the disease dominant optic atrophy, provide insight into how structural features of OPA1 enable this protein to mediate mitochondrial-membrane fusion and remodelling.

    • Sarah B. Nyenhuis
    • Xufeng Wu
    • Jenny E. Hinshaw
    Research
    Nature
    Volume: 620, P: 1109-1116

  • Folded proteins are composed of secondary structures, α-helices and β-sheets, that are generally assumed to be stable. Here, the authors combine computational prediction with experimental validation to show that many sequence-diverse NusG protein domains switch completely from α-helix to β-sheet folds.

    • Lauren L. Porter
    • Allen K. Kim
    • Marie-Paule Strub
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • The integration and organization of growth factor signaling, adhesion, and endocytosis is poorly understood. Here the authors use light and electron microscopy to shed light on the role of flat clathrin lattices and cell adhesion in growth factor signaling.

    • Marco A. Alfonzo-Méndez
    • Kem A. Sochacki
    • Justin W. Taraska
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • The molecular organization of exocytic vesicles regulates their transport and fusion. Prasai, Taraska, and colleagues use correlative light and electron microscopy, along with 3D tomography and gold labeling, to directly map proteins on single exocytic organelles at the plasma membrane.

    • Bijeta Prasai
    • Gideon J. Haber
    • Justin W. Taraska
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Conformational changes within proteins are thought to regulate clathrin-mediated endocytosis. Here, authors develop a correlative FRET and EM imaging method and uncover a structural switch in clathrin light chain that controls endocytosis in cells.

    • Kazuki Obashi
    • Kem A. Sochacki
    • Justin W. Taraska
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Tsg101 is a component of the host cellular ESCRT machinery and is required for HIV-1 replication. Here, the authors show that disruption of ubiquitin binding of the Tsg101 UEV domain through commonly used drugs arrests virus assembly, which might facilitate the development of potent HIV inhibitors.

    • Madeleine Strickland
    • Lorna S. Ehrlich
    • Carol A. Carter
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • A cryo-electron microscopy structure of human dynamin-1 demonstrates conformational changes and sheds light on the fission of membranes during endocytosis.

    • Leopold Kong
    • Kem A. Sochacki
    • Jenny E. Hinshaw
    Research
    Nature
    Volume: 560, P: 258-262