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Investigating the neuronal role of the proteasomal ATPase subunit gene PSMC5 in neurodevelopmental proteasomopathies

Variants in the PSMC5 gene impair proteasome function and cellular homeostasis, altering brain development in children. This study reveals underlying molecular mechanisms contributing to this neurodevelopmental phenotype, and suggests therapeutic leads for neurodevelopmental proteasomopathies.

Sébastien Küry
Janelle E. Stanton
Elke Krüger
ResearchOpen Access26 Nov 2025
Nature Communications

Volume: 16, P: 1-21
Conformational maps of human 20S proteasomes reveal PA28- and immuno-dependent inter-ring crosstalks

Immune cells express immunoproteasomes (i20S), which bind to specialized regulators, contain different catalytic subunits and generate immunogenic peptides. HDX-MS—based assessment of the differences between the conformational dynamics of standard and i20s reveals specific, allosteric changes in i20S and upon regulator binding.

Jean Lesne
Marie Locard-Paulet
Julien Marcoux
ResearchOpen Access01 Dec 2020
Nature Communications

Volume: 11, P: 1-15
Familial correlations and inter-relationships of four asthma-associated quantitative phenotypes in 320 French EGEA families ascertained through asthmatic probands

Emmanuelle Bouzigon
Valérie Chaudru
Florence Demenais
Research07 Jul 2004
European Journal of Human Genetics

Volume: 12, P: 955-963
Efficiency of the four proteasome subtypes to degrade ubiquitinated or oxidized proteins

Joanna Abi Habib
Etienne De Plaen
Benoit J. Van den Eynde
ResearchOpen Access25 Sept 2020
Scientific Reports

Volume: 10, P: 1-17
HadD, a novel fatty acid synthase type II protein, is essential for alpha- and epoxy-mycolic acid biosynthesis and mycobacterial fitness

Cyril Lefebvre
Richard Boulon
Annaïk Quémard
ResearchOpen Access16 Apr 2018
Scientific Reports

Volume: 8, P: 1-15
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22

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Investigating the neuronal role of the proteasomal ATPase subunit gene PSMC5 in neurodevelopmental proteasomopathies

Conformational maps of human 20S proteasomes reveal PA28- and immuno-dependent inter-ring crosstalks

Familial correlations and inter-relationships of four asthma-associated quantitative phenotypes in 320 French EGEA families ascertained through asthmatic probands

Efficiency of the four proteasome subtypes to degrade ubiquitinated or oxidized proteins

HadD, a novel fatty acid synthase type II protein, is essential for alpha- and epoxy-mycolic acid biosynthesis and mycobacterial fitness

At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

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