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A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain

Necroptosis drives arthritis. Polykratis et al. show that the deubiquitinating enzyme A20 inhibits inflammasome-dependent arthritis development by regulating macrophage necroptosis and this function depends on its ZnF7 ubiquitin binding domain.

Apostolos Polykratis
Arne Martens
Manolis Pasparakis
Research13 May 2019
Nature Cell Biology

Volume: 21, P: 731-742
The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts

TNF is a major therapeutic target for rheumatoid arthritis (RA) and synovial fibroblasts are central to the pathogenesis of RA. Here the authors dissect TNF-induced death and activation signalling in RA synovial fibroblasts and TNF-driven arthritis and indicate that a successful therapeutic strategy might be to target both IKK2 and RIPK3 at the same time.

Marietta Armaka
Caroline Ospelt
George Kollias
ResearchOpen Access12 Feb 2018
Nature Communications

Volume: 9, P: 1-12
The mesenchymal context in inflammation, immunity and cancer

Koliaraki, Prados, Armaka & Kollias review the roles of fibroblastic mesenchymal cells in tissue homeostasis and immunopathologic diseases, including chronic inflammatory disease, tissue fibrosis and cancer.

Vasiliki Koliaraki
Alejandro Prados
George Kollias
Reviews03 Aug 2020
Nature Immunology

Volume: 21, P: 974-982
The long non-coding RNA HOTAIR contributes to joint-specific gene expression in rheumatoid arthritis

Although patients with rheumatoid arthritis (RA) usually exhibit symmetrical joint involvement, some can develop alternative patterns of arthritis, often translating into differences in responsiveness to treatment. In this study, the authors propose that the long-noncoding RNA, HOTAIR, might contribute to these differences.

Muriel Elhai
Raphael Micheroli
Caroline Ospelt
ResearchOpen Access09 Dec 2023
Nature Communications

Volume: 14, P: 1-19
Cyld restrains the hyperactivation of synovial fibroblasts in inflammatory arthritis by regulating the TAK1/IKK2 signaling axis

Vagelis Rinotas
Kalliopi Iliaki
Marietta Armaka
ResearchOpen Access09 Aug 2024
Cell Death & Disease

Volume: 15, P: 1-9
Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities

van Loo and colleagues provide insights into the action of the anti-inflammatory protein A20. The ZnF7 and ZnF4 ubiquitin-binding domains of A20 are both required to suppress inflammatory signaling and cell death; however, these zinc fingers operate via distinct mechanisms.

Arne Martens
Dario Priem
Geert van Loo
Research16 Mar 2020
Nature Immunology

Volume: 21, P: 381-387
RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury

Santosh Krishna-Subramanian
Stephan Singer
Vangelis Kondylis
Research15 Apr 2019
Cell Death & Differentiation

Volume: 26, P: 2710-2726

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A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain

The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts

The mesenchymal context in inflammation, immunity and cancer

The long non-coding RNA HOTAIR contributes to joint-specific gene expression in rheumatoid arthritis

Cyld restrains the hyperactivation of synovial fibroblasts in inflammatory arthritis by regulating the TAK1/IKK2 signaling axis

Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities

RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury

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