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Showing 1–5 of 5 results
Advanced filters: Author: Marina Bennati Clear advanced filters

  • The analysis of complex (bio)molecules by NMR spectroscopy is often complicated by limitations in sensitivity. Now, it has been shown that 13C NMR signals are strongly enhanced in solution by resonant microwave irradiation of a nitroxide polarizer. This method exhibits up to one-thousand-fold improvements in sensitivity, which stands to greatly improve the detail with which small molecules and metabolites can be studied.

    • Guoquan Liu
    • Marcel Levien
    • Marina Bennati
    Research
    Nature Chemistry
    Volume: 9, P: 676-680

  • The existence, nature and biological relevance of mechanoradicals in proteins are unknown. Here authors show that mechanical stress on collagen produces radicals and subsequently reactive oxygen species and suggest that collagen I evolved as a radical sponge against mechano-oxidative damage.

    • Christopher Zapp
    • Agnieszka Obarska-Kosinska
    • Frauke Gräter
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-8

  • Parkinson’s disease (PD) and Multiple System Atrophy (MSA) are characterized by the pathological accumulation of α-synuclein. Here the authors employ fluorescent probes, electron microscopy and NMR spectroscopy to study the properties of α-synuclein aggregates that were amplified from patient brain extracts and observe a greater structural diversity among PD patients compared to MSA patients.

    • Timo Strohäker
    • Byung Chul Jung
    • Markus Zweckstetter
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12