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Showing 1–4 of 4 results
Advanced filters: Author: Marina Feric Clear advanced filters

  • Single-molecule experiments can now quantify the surface forces that compete to package tethered DNA into a protein-rich condensate — providing much-needed mechanistic insight into the phase behaviour of the entangled genome in the nucleus.

    • Marina Feric
    News & Views
    Nature Physics
    Volume: 17, P: 981-982

  • Ultrafast-scanning fluorescence correlation spectroscopy has now been used to measure the molecular interactions underlying the phase behaviour of disordered proteins. Sequence-encoded conformational fluctuations of these proteins are shown to give rise to phase-separated droplets of surprisingly low concentrations. These results provide insight into how the structural features of the droplets affect the properties of liquid-phase intracellular organelles.

    • Ming-Tzo Wei
    • Shana Elbaum-Garfinkle
    • Clifford P. Brangwynne
    Research
    Nature Chemistry
    Volume: 9, P: 1118-1125