Pancreatic stellate cells are the main mediator of fibrogenesis during chronic pancreatitis, and chronic pancreatitis is a consistent risk factor for pancreatic ductal adenocarcinoma. In this Review, the authors discuss the idea that pancreatic stellate cells have a linking role in the development of pancreatic ductal adenocarcinoma via their ability to communicate with inflammatory cells, acinar cells and pancreatic cancer cells.
- Hana Algül
- Matthias Treiber
- Roland M Schmid
