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Showing 1–15 of 15 results
Advanced filters: Author: Marina Ryzhova Clear advanced filters

  • Analyses of primary and relapse samples of embryonal tumours with multilayered rosettes provide insights into the molecular mechanisms that underlie the development and opportunities for the treatment of this deadly disease.

    • Sander Lambo
    • Susanne N. Gröbner
    • Marcel Kool
    Research
    Nature
    Volume: 576, P: 274-280

  • Radiation-induced gliomas (RIGs) have been reported in patients after treatment with cranial irradiation for various primary malignancies but their origin are still unclear. Here, the authors define the genomic, epigenetic and transcriptional landscape of 32 RIGs cases.

    • Maximilian Y. Deng
    • Dominik Sturm
    • David T. W. Jones
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • An online approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups has been developed to help to improve current diagnostic standards.

    • David Capper
    • David T. W. Jones
    • Stefan M. Pfister
    Research
    Nature
    Volume: 555, P: 469-474

  • Genomic analysis of 491 medulloblastoma samples, including methylation profiling of 1,256 cases, effectively assigns candidate drivers to most tumours across all molecular subgroups.

    • Paul A. Northcott
    • Ivo Buchhalter
    • Peter Lichter
    ResearchOpen Access
    Nature
    Volume: 547, P: 311-317

  • Focusing on two ill-characterized subtypes of medulloblastoma (group 3 and group 4), this study identifies prevalent genomic structural variants that are restricted to these two subtypes and independently bring together coding regions of GFI1 family proto-oncogenes with active enhancer elements, leading to their mutually exclusive oncogenic activation.

    • Paul A. Northcott
    • Catherine Lee
    • Stefan M. Pfister
    Research
    Nature
    Volume: 511, P: 428-434

  • Genomic studies of the paediatric brain tumour medulloblastoma have revealed four clinically distinct molecular subgroups; here active gene regulatory elements in 28 primary medulloblastoma tissues are mapped to reveal differentially regulated enhancers across the different subgroups, allowing insights into the transcription factors that characterize subgroup divergence and the cellular origin of the poorly characterized Group 3 and 4 subgroups.

    • Charles Y. Lin
    • Serap Erkek
    • Paul A. Northcott
    Research
    Nature
    Volume: 530, P: 57-62

  • Stefan Pfister and the ICGC PedBrain Tumor Project report whole-genome sequencing of 96 pilocytic astrocytomas. They identify recurrent activating mutations in FGFR1 and PTPN11 and novel NTRK2 fusion genes.

    • David T W Jones
    • Barbara Hutter
    • Stefan M Pfister
    Research
    Nature Genetics
    Volume: 45, P: 927-932

  • Medulloblastoma is the most common brain tumour in children; using whole-genome sequencing of tumour samples the authors show that the clinically challenging Group 3 and 4 tumours can be tetraploid, and reveal the expression of the first medulloblastoma fusion genes identified.

    • David T. W. Jones
    • Natalie Jäger
    • Peter Lichter
    ResearchOpen Access
    Nature
    Volume: 488, P: 100-105

  • Medulloblastoma is a malignant childhood brain tumour presenting major clinical challenges; here, a comprehensive genome-wide DNA methylation data set from human and mouse tumours, coupled with analysis of histone modifications, RNA transcripts and genome sequencing, uncovers a wealth of alterations that provide insights into the epigenetic regulation of transcription and genome organization in medulloblastoma pathogenesis.

    • Volker Hovestadt
    • David T. W. Jones
    • Peter Lichter
    Research
    Nature
    Volume: 510, P: 537-541