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Showing 1–4 of 4 results
Advanced filters: Author: Marina Schrecker Clear advanced filters

  • Schrecker, Son and colleagues identify the accessory subunits transmembrane protein 9 (TMEM9) and TMEM9B for chloride transporters ClC-3, ClC-4 and ClC-5 and establish the roles of TMEM9 and phosphatidylinositol 3,5-bisphosphate in the regulation of ClC-3 activity and endosomal ion homeostasis.

    • Marina Schrecker
    • Yeeun Son
    • Richard K. Hite
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 32, P: 1972-1979

  • Cryo-EM structures of the yeast 9-1-1 checkpoint clamp in complex with the Rad24-RFC clamp loader and a DNA substrate explain how 9-1-1 is recruited to DNA junctions with recessed 5′ ends and reveal the mechanism of sliding clamp loading.

    • Juan C. Castaneda
    • Marina Schrecker
    • Richard K. Hite
    Research
    Nature Structural & Molecular Biology
    Volume: 29, P: 369-375

  • Endosomal function depends on luminal ion homeostasis. Here the authors identify TMEM9 and TMEM9B as inhibitory subunits of endosomal ClC-3 to ClC−5 that prevent endosomal swelling and disease by regulating their Cl−/H+ exchange and trafficking.

    • Rosa Planells-Cases
    • Viktoriia Vorobeva
    • Thomas J. Jentsch
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17