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Showing 1–1 of 1 results
Advanced filters: Author: Mario Aladren Vicente Clear advanced filters

  • BRAF or MEK1/2 inhibitors are cytostatic in melanoma and the surviving cells develop drug resistance. This study shows that the pro-survival pool is biased towards MCL1 in melanoma so that BRAF or MEK1/2 inhibitors are synthetic lethal with the MCL1 inhibitor AZD5991, improving tumour growth inhibition.

    • Matthew J. Sale
    • Emma Minihane
    • Simon J. Cook
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-19