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Showing 1–4 of 4 results
Advanced filters: Author: Mario Bonalli Clear advanced filters

  • ADP-ribosylation is an important post-translational protein modification, yet enzymes capable of removing the protein-proximal ADP-ribose were unknown. Human macrodomain proteins MacroD1, D2 and C6orf130 are now shown to catalyze mono-ADP-ribose removal. MacroD2 is also shown to reverse the inhibition of GSK3A caused by ARTD10-catalyzed mono-ADP-ribosylation.

    • Florian Rosenthal
    • Karla L H Feijs
    • Michael O Hottiger
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 502-507

  • The epigenetic modifier EZH2 is highly expressed in melanoma but its role in cancer initiation and progression is still unclear. Here the authors use mouse models and human cell lines to show that EZH2 has an essential role in melanoma progression and metastasis, thus highlighting its potential as a therapeutic target.

    • Daniel Zingg
    • Julien Debbache
    • Lukas Sommer
    Research
    Nature Communications
    Volume: 6, P: 1-17

  • The aggressive nature of melanoma cells relies on their ability to switch from a high-proliferative/low-invasive to a low-proliferative/high-invasive state; however, the mechanisms governing this switch are unclear. Here, using in vivo models of human melanoma, the authors show that CD271 is a key regulator of phenotype switching and metastasis formation.

    • Gaetana Restivo
    • Johanna Diener
    • Lukas Sommer
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16