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Showing 1–3 of 3 results
Advanced filters: Author: Mario H. Bengtson Clear advanced filters

  • The translation of messenger RNA that lacks stop codons results in the production of aberrant proteins, which may have harmful effects on the cell. It is unclear how eukaryotic cells eliminate these 'non-stop' proteins. Here it is shown that, in Saccharomyces cerevisiae, an E3 ubiquitin ligase called Ltn1 acts in the quality-control pathway. It associates with ribosomes and marks non-stop proteins with ubiquitin, which targets the proteins for degradation.

    • Mario H. Bengtson
    • Claudio A. P. Joazeiro
    Research
    Nature
    Volume: 467, P: 470-473

  • The Structural Genomics Consortium (SGC) and its clinical, industry and disease-foundation partners are launching open-source preclinical translational medicine studies.

    • Aled M. Edwards
    • Cheryl H. Arrowsmith
    • L. Trevor Young
    Comments & Opinion
    Nature Reviews Drug Discovery
    Volume: 14, P: 149-150

  • Target 2035 aims to develop a potent and selective pharmacological modulator for every human protein by 2035 with the results made publicly available. This Roadmap article sets out how that will be achieved.

    • Aled M. Edwards
    • Dafydd R. Owen
    • Suzanne Ackloo
    Reviews
    Nature Reviews Chemistry
    Volume: 9, P: 634-645