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Showing 1–5 of 5 results
Advanced filters: Author: Mario Novkovic Clear advanced filters

  • Morphogens such as chemokines form gradients to direct graded responses and modulate cell behaviors. Here the authors show, using imaging and computer simulation, that the chemokine CXCL13 originated from follicular reticular cells in the lymph nodes forms both soluble and immobilized gradients to regulate B cell recruitment and migration.

    • Jason Cosgrove
    • Mario Novkovic
    • Mark C. Coles
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • Fibroblastic reticular cells (FRCs) support localisation of immune cells in secondary lymphoid tissues but less is known about the lamina propria. Here the authors use scRNA-seq and intestinal infection to characterise FRCs in the intestinal lamina propria and show specialised niches that foster innate lymphoid cells during homeostasis and infection.

    • Hung-Wei Cheng
    • Urs Mörbe
    • Burkhard Ludewig
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • The white pulp of spleen is an important immune structure dynamically modulated during development and immune responses. Here the authors define, using multi-color lineage tracing and single-cell transcriptome analysis, the subset distribution and differentiation trajectory of fibroblastic reticular cells to serve structural insights for splenic white pulps.

    • Hung-Wei Cheng
    • Lucas Onder
    • Burkhard Ludewig
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Fibroblastic reticular cells influence the function of lymphocytes in secondary lymphoid organs. Ludewig and colleagues demonstrate that they also specifically restrain the activation of group 1 innate lymphoid cells in the presence of microbial stimulation to prevent immunopathology.

    • Cristina Gil-Cruz
    • Christian Perez-Shibayama
    • Burkhard Ludewig
    Research
    Nature Immunology
    Volume: 17, P: 1388-1396