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Showing 1–4 of 4 results
Advanced filters: Author: Mario Pujato Clear advanced filters

  • Linking transcription factors with disease loci implicates EBNA2, encoded by Epstein–Barr virus, in autoimmune diseases. Applying the method more widely identifies associations for hundreds of transcription factors, illuminating disease mechanisms.

    • John B. Harley
    • Xiaoting Chen
    • Matthew T. Weirauch
    Research
    Nature Genetics
    Volume: 50, P: 699-707

  • Thousands of genetic variants have been associated with lupus, but causal variants and mechanisms are unknown. Here, the authors combine a massively parallel reporter assay with genome-wide ChIP experiments to identify risk variants with allelic enhancer activity mediated through transcription factor binding.

    • Xiaoming Lu
    • Xiaoting Chen
    • Leah C. Kottyan
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Langerhans cells (LC) can prime tolerogenic as well as immunogenic responses in the skin. Here the authors show, by transcriptomic, epigenetic and CRISPR editing analyses, that during LC migration and maturation the transcription factor IRF4 regulates expression of antigen presentation and co-stimulatory gene modules while attenuating inflammatory response genes.

    • Sofia Sirvent
    • Andres F. Vallejo
    • Marta E. Polak
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12