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Showing 1–14 of 14 results
Advanced filters: Author: Mario Scheel Clear advanced filters

  • MCL1 is an anti-apoptotic protein associated with cancer and therapy resistance. Here, the authors show that MCL1 regulates mTORC1 signalling and metabolism, explaining MCL1-inhibition reported cardiotoxicity, which can be mitigated by dietary leucine supplementation.

    • Wentao Gui
    • Petr Paral
    • Mohamed Elgendy
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • It is important to understand the mechanisms of thermally induced battery degradation and any safety hazards. Here, the authors use high-speed synchrotron radiation X-ray computed tomography to shed light on the structural and thermal dynamics associated with thermal runaway and failure of commercial Li-ion batteries.

    • Donal P. Finegan
    • Mario Scheel
    • Paul R. Shearing
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10

  • Following the impact of the protoplanet Theia, planet Earth likely transformed into a magma ocean. New high temperature and pressure experiments by Xie et al. suggest that a layer enriched in bridgmanite formed during the magma ocean phase of Earth–remnants of this ancient layer today may be responsible for the viscosity peak between 660 and 1500 km in present solid mantle.

    • Longjian Xie
    • Akira Yoneda
    • Denis Andrault
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Medulloblastomas (MBs) are highly heterogeneous paediatric brain tumours that remain challenging to treat. Here, the authors integrate proteomics, epigenomics, transcriptomics and post-translational modification analyses to find molecular subgroups and potential therapeutic targets in MB tumours.

    • Shweta Godbole
    • Hannah Voß
    • Julia E. Neumann
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-24

  • A neural epigenetic signature detectable via plasma analyses is prognostic in patients with glioblastoma, resembling an oligodendrocyte-progenitor- and neuronal-progenitor-cell-like state and showing increased neuro-to-glioma synapse formation.

    • Richard Drexler
    • Robin Khatri
    • Franz L. Ricklefs
    ResearchOpen Access
    Nature Medicine
    Volume: 30, P: 1622-1635

  • Caloric restriction (CR) has been demonstrated to have a role in tumour growth and therapy response but its effects on cancer stem cells are less known. Here, in Acute Promyelocytic Leukemia, the authors show that despite initial anti-tumour effect, CR drives the selection of leukaemia-initiating cells resulting in relapse which could be prevented by ablation of LSD1.

    • Rani Pallavi
    • Elena Gatti
    • Pier Giuseppe Pelicci
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Neurons form synapses onto glioma cells, and depolarization of glioma membranes promotes glioma growth in vivo, whereas blocking electrochemical signalling blocks tumour growth.

    • Humsa S. Venkatesh
    • Wade Morishita
    • Michelle Monje
    Research
    Nature
    Volume: 573, P: 539-545

  • The genome of the gibbon, a tree-dwelling ape from Asia positioned between Old World monkeys and the great apes, is presented, providing insights into the evolutionary history of gibbon species and their accelerated karyotypes, as well as evidence for selection of genes such as those for forelimb development and connective tissue that may be important for locomotion through trees.

    • Lucia Carbone
    • R. Alan Harris
    • Richard A. Gibbs
    ResearchOpen Access
    Nature
    Volume: 513, P: 195-201

  • Science strives towards a credible and comprehensive understanding of the world around us. Across disciplines within the social and behavioural sciences (and beyond), limitations in the implementation of the scientific approach have been identified in recent studies, showing low replicability of many results. This is an issue for knowledge accumulation, theory-building, and evidence-based decision and policy making. Researchers have proposed several solutions to address these issues, focusing mainly on improving statistical methods, data quality, and transparency. However, relatively little attention has been paid to another key aspect that affects replicability: language. Across fields, language plays a central role in all steps of the research cycle and is a critical communication tool among researchers. Neglecting its role may reduce replicability and limit our understanding of theoretically interesting differences and similarities across languages. After identifying these challenges, we provide some recommendations and an outlook on how replicability challenges related to language may be addressed.

    • Xenia Schmalz
    • Johannes Breuer
    • Timo Roettger
    Comments & OpinionOpen Access
    Humanities and Social Sciences Communications
    Volume: 12, P: 1-6