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Showing 1–7 of 7 results
Advanced filters: Author: Marion Pardons Clear advanced filters

  • Here, Pardons and Lambrechts et al show that HIV-1 reservoirs in blood and lymph nodes differ phenotypically. Furthermore, germinal center T follicular helper cells do not harbor the inducible reservoir in long-term suppressed individuals. Infected clones can spread across tissues and persist without active replication.

    • Marion Pardons
    • Laurens Lambrechts
    • Linos Vandekerckhove
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • HIV remission of more than 6 years was achieved in a patient with functional viral co-receptors after CCR5 wild-type/Δ32 allogeneic stem cell transplantation, providing evidence of other mechanisms that can be harnessed to attain long-term remission.

    • Christian Gaebler
    • Samad Kor
    • Olaf Penack
    ResearchOpen Access
    Nature
    P: 1-9

  • To provide in depth characterization of HIV reservoir cells, the authors here develop a single-cell approach to simultaneously sequence TCR, integration sites and proviral genomes, called STIP-Seq, and show that the translation-competent reservoir mainly consists of proviruses with short deletions at the 5’-end of the genome.

    • Basiel Cole
    • Laurens Lambrechts
    • Linos Vandekerckhove
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Reactivating latent HIV reservoirs could be beneficial towards a functional cure. Here, the authors show that Tat-LNP effectively reactivates HIV while preserving the cell transcriptome. Upon reactivation, p24+ cells exhibit distinct genes and pathways potentially contributing to their persistence.

    • Marion Pardons
    • Basiel Cole
    • Linos Vandekerckhove
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • Here, the authors apply positron emission tomography (PET) imaging to visualize HIV tissue-wide burden in infected individuals using a radiolabeled broadly neutralizing antibody, 89Zr-VRC01, and show that PET tracer lymph node uptake positively correlates with HIV protein levels measured directly from cells obtained from these tissues. This strategy may allow non-invasive characterization of residual HIV infection in the setting of therapeutic interventions.

    • Denis R. Beckford-Vera
    • Robert R. Flavell
    • Timothy J. Henrich
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Some HIV-infected cells persist during antiretroviral therapies (ART) but their phenotype is less clear. Dufour et al. show that HIV-infected cells that persist in people receiving ART are phenotypically diverse and that CD4+ T cells expressing the integrin VLA-4 are highly enriched in replication-competent HIV.

    • Caroline Dufour
    • Corentin Richard
    • Nicolas Chomont
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • The cause of clonal expansions in the HIV reservoir remains unclear. Here, Gantner et al. perform single-cell TCR sequencing on longitudinal samples from eight individuals on antiretroviral therapy and find that antigens inducing clonal expansions of memory cells are major contributors to the HIV reservoir.

    • Pierre Gantner
    • Amélie Pagliuzza
    • Nicolas Chomont
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9