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Showing 1–18 of 18 results
Advanced filters: Author: Mariona Graupera Clear advanced filters

  • Endothelial cells in white adipose tissue are shown to produce polyamines, which regulate adipocyte lipolysis, thus demonstrating how local angiocrine signals contribute to healthy adipose tissue homeostasis.

    • Erika Monelli
    • Pilar Villacampa
    • Mariona Graupera
    Research
    Nature Metabolism
    Volume: 4, P: 327-343

  • Torrano et al. use bioinformatics analyses to identify PGC1α as a transcriptional regulator of a metabolic program downstream of ERRα that opposes metastatic dissemination in prostate cancer.

    • Veronica Torrano
    • Lorea Valcarcel-Jimenez
    • Arkaitz Carracedo
    Research
    Nature Cell Biology
    Volume: 18, P: 645-656

  • Phosphoinositide 3-kinases (PI3Ks), of which there are eight isoforms, function early in intracellular signal transduction pathways and affect many biological functions. Understanding how these isoforms are differentially regulated and how they control signalling might provide new insight into their roles in disease.

    • Bart Vanhaesebroeck
    • Julie Guillermet-Guibert
    • Benoit Bilanges
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 11, P: 329-341

  • Here the authors uncover p53’s role as the master regulator of spatio-temporal genome organization. p53 controls the expression of 340 distal genes through newly formed and pre-existing loops between p53-bound enhancers and promoters.

    • François Serra
    • Andrea Nieto-Aliseda
    • Biola M. Javierre
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • Lymphatic malformation (LM) is a debilitating often incurable vascular disease. Using a mouse model of LM driven by a disease-causative PIK3CA mutation, the authors show that vascular growth is dependent on the upstream lymphangiogenic VEGF-C signalling, permitting effective therapeutic intervention.

    • Ines Martinez-Corral
    • Yan Zhang
    • Taija Mäkinen
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • High-dimensional datasets derived from time-resolved live imaging of leukocytes in mice were used to identify leukocyte identities and dynamic neutrophil states with high cellular resolution.

    • Georgiana Crainiciuc
    • Miguel Palomino-Segura
    • Andrés Hidalgo
    Research
    Nature
    Volume: 601, P: 415-421

  • Communication between endothelial leader and follower cells during collective cell migration is crucial for vascular development. Here, the authors show that PACSIN2 guides collective cell migration and angiogenesis by recruiting a protein trafficking complex to asymmetric cell-cell junctions, controlling local junction plasticity.

    • Tsveta S. Malinova
    • Ana Angulo-Urarte
    • Stephan Huveneers
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • Angiogenesis requires dynamic endothelial rearrangements and relative position changes within the vascular tubes. Here the authors show that a PI3K/NUAK1/MYPT1/MLCP pathway regulates actomyosin contractility in endothelial cells and cellular rearrangement during vascular patterning.

    • Ana Angulo-Urarte
    • Pedro Casado
    • Mariona Graupera
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16

  • During the formation of vascular sprouts, Notch activation inhibits proliferation of the stalk ECs via unknown mechanism. Here the authors show that PTEN represents a critical mediator of Notch anti-proliferative response in stalk cells via its phosphatase-dependent and -independent activity.

    • Helena Serra
    • Iñigo Chivite
    • Mariona Graupera
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13

  • Arteriovenous malformations (AVM) is a hallmark of hereditary haemorrhagic telangiectasia type 2, a disease caused by mutations in BMP receptor ALK1. Ola et al. show that AVM can be caused by blocking BMP9 and BMP10 in mice, leading to increased VEGF and PI3K activity, and that pharmacologic inhibition of PI3K prevents AVM development.

    • Roxana Ola
    • Alexandre Dubrac
    • Anne Eichmann
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • Activated PI3K causes cancer, but the role of active PI3K mutations in early stages of malignancy are unclear. Here, the authors show in a mouse model that active PI3K induces centrosome amplification via AKT, ROCK, CDK2/Cyclin E and nucleophosmin, and increased tolerance of genome doubling.

    • Inma M. Berenjeno
    • Roberto Piñeiro
    • Bart Vanhaesebroeck
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15

  • The p110α isoform of phosphoinositide 3-kinase has a critical role in angiogenesis. In particular, it is needed to mediate the migration of endothelial cells downstream of VEGF receptor activation, acting upstream of RhoA. The results suggest that pharmacological inhibition of the p110α isoform may be useful in anti-angiogenesis therapy of cancer.

    • Mariona Graupera
    • Julie Guillermet-Guibert
    • Bart Vanhaesebroeck
    Research
    Nature
    Volume: 453, P: 662-666

  • In this Review, the authors provide an overview of the pathogenic effects of somatic activating PIK3CA mutations in congenital disorders and discuss how the interplay between genetics, cell identity and the environment explains the onset, progression and severity of these disorders with a special focus on the vasculature.

    • Ana Angulo-Urarte
    • Mariona Graupera
    Reviews
    Nature Cardiovascular Research
    Volume: 1, P: 700-714