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Showing 1–12 of 12 results
Advanced filters: Author: Marisa L. Martin-Fernandez Clear advanced filters

  • Broad uptake of smFRET has been hindered by high instrument costs and a lack of open-source hardware and acquisition software. Here, the authors present the smfBox, a cost-effective open-source platform capable of measuring precise FRET efficiencies between dyes on freely diffusing single molecules.

    • Benjamin Ambrose
    • James M. Baxter
    • Timothy D. Craggs
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-6

  • The Epidermal Growth Factor Receptor (EGFR) is frequently found to be mutated in non-small cell lung cancer. Here, the authors show that EGFR lung cancer mutations promote the assembly of kinase-active dimers within ligand-free EGFR oligomers. These dimers bind ligand with high affinity and promote tumor growth.

    • R. Sumanth Iyer
    • Sarah R. Needham
    • Marisa L. Martin-Fernandez
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21

  • Epidermal growth factor receptors have been shown to oligomerise upon binding to their cognate ligands. Here, the authors use biochemical, biophysical and cell biology techniques to analyse the structures of these oligomers, and argue that these formations are required for signalling.

    • Sarah R. Needham
    • Selene K. Roberts
    • Marisa L. Martin-Fernandez
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14

  • To prevent ligand-independent dimerisation the epidermal growth factor receptor (EGFR) is autoinhibited by an extracellular dimer interaction. Here, the authors use several imaging technologies and simulations to provide structural insights on the inactive species and on how intracellular mutations circumvent the autoinhibition of the basal state.

    • Laura C. Zanetti-Domingues
    • Dimitrios Korovesis
    • Marisa L. Martin-Fernandez
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17

  • Single-molecule localization microscopy visualizes individual biological molecules but suffers from sample drift that degrades resolution. Hao Qiu and colleagues present reinforced optical cage systems to readily prevent drift for uncompromised resolution

    • Hao Qiu
    • Matthew C. Tang
    • Lin Wang
    ResearchOpen Access
    Communications Engineering
    Volume: 5, P: 1-15

  • Particulate methane monooxygenase (pMMO) is the main enzyme used by methanotrophs. Here, the authors determined the native structure of pMMO by cryo-electron tomography, revealing lipid-stabilized features and a higher-order hexagonal array arrangement in intact cells.

    • Yanan Zhu
    • Christopher W. Koo
    • Peijun Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • In this study, Peijun Zhang and colleagues use cryoFIB/SEM volume imaging and soft x-ray cryo-tomography with cryo-electron tomography (cryoET) of cellular periphery, lamellae, and subtomogram averaging to place critical structural events in the SARS-CoV-2 infection cycle in the context of whole-cell images.

    • Luiza Mendonça
    • Andrew Howe
    • Peijun Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • An autophagy receptor, NDP52, is recruited to the nucleus where it can bind DNA. The authors show this promotes changes in chromatin accessibility which supports transcription initiation, providing a direct link between autophagy and transcription regulation.

    • Ália dos Santos
    • Daniel E. Rollins
    • Christopher P. Toseland
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-24

  • The actin-based molecular motors, myosins, have also been linked to transcription, but their precise role has remained elusive. Here the authors show RNA polymerase II (RNAPII) is lost from chromatin upon myosin perturbation and that myosin acts as a molecular anchor to maintain RNAPII spatial organisation.

    • Yukti Hari-Gupta
    • Natalia Fili
    • Christopher P. Toseland
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • Replication of Toxoplasma gondii requires replication and distribution of essential organelles such as micronemes. Here, Periz et al. show that micronemes are recycled from the mother to the forming daughter cells using a highly dynamic F-actin network that supports multidirectional vesicle transport.

    • Javier Periz
    • Mario Del Rosario
    • Markus Meissner
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • Lin Wang et al. present a new super-resolution modality using a super-hemispherical immersion lens. They achieve a 12 nm spatial resolution in cells under cryogenic conditions, which offers the technical means to study bacterial and mammalian cell samples at molecule localisation length-scales.

    • Lin Wang
    • Benji Bateman
    • Marisa L. Martin-Fernandez
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-11