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Showing 1–5 of 5 results
Advanced filters: Author: Marit W. Vermunt Clear advanced filters

  • Luan et al. find that CTCF shapes the transcriptional landscape in part by suppressing the initiation of upstream antisense transcription at hundreds of divergent gene promoters.

    • Jing Luan
    • Marit W. Vermunt
    • Gerd A. Blobel
    Research
    Nature Structural & Molecular Biology
    Volume: 29, P: 1136-1144

  • The understanding of the changes regulating gene expression relevant for the emergence of the human brain and its susceptibility to disease is limited. Here, the authors identified a set of regulatory elements that evolved in hominins affecting oligodendrocyte function, and link these to autism.

    • Bas Castelijns
    • Mirna L. Baak
    • Menno P. Creyghton
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Sustained cardiac function depends on circadian REV-ERBs. Here, Dierickx et al. show that circadian nuclear receptors REV-ERBα and β are indispensable to establish the transcriptional program that controls cardiac metabolism and NAD+ production. Deregulation of REV-ERBs leads to dilated cardiomyopathy and premature death.

    • Pieterjan Dierickx
    • Kun Zhu
    • Mitchell A. Lazar
    Research
    Nature Cardiovascular Research
    Volume: 1, P: 45-58

  • Higher-order chromatin structure is temporarily disrupted during mitosis. Here the authors show that loss of the architectural factor CTCF results in failure to form structural loops and leads to inappropriate cis-regulatory contacts and alterations of compartmental interactions after mitosis. Furthermore, they show global 3D architecture is set up without transcription, but that transcription contributes to proper gene domain formation.

    • Haoyue Zhang
    • Jessica Lam
    • Gerd A. Blobel
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Gene-regulatory elements are drivers of evolutionary divergence, yet where these are located and which are evolutionarily relevant is unclear. In this work, large-scale epigenomic analysis of human, rhesus and chimpanzee brain tissue allowed the identification of human-specific gene-regulatory changes that contributed to the emergence of the human brain.

    • Marit W Vermunt
    • Sander C Tan
    • Menno P Creyghton
    Research
    Nature Neuroscience
    Volume: 19, P: 494-503