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Showing 1–6 of 6 results
Advanced filters: Author: Maritta Kunert Clear advanced filters

  • Ipecac alkaloids are plant-derived compounds historically used to induce vomiting. Here the authors elucidate how two evolutionary distant plant species have evolved to produce the same ipecac alkaloid.

    • Maite Colinas
    • Clara Morweiser
    • Sarah E. O’Connor
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 21, P: 1794-1805

  • The incorporation of nitrogen in steroidal glycoalkaloids is hypothesized to occur through a transamination reaction. Here, the authors show that GLYCOALKALOID METABOLISM12 appears to evolve from the canonical γ-aminobutyric acid transaminases and directs the biosynthesis of nitrogen-containing steroidal metabolites in Solanum plants.

    • Dagny Grzech
    • Samuel J. Smit
    • Prashant D. Sonawane
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 21, P: 131-142

  • Iridoid compounds are an important class of natural products. Here, the authors report on the discovery and engineering of nepetalactol-related short chain reductases and their application for the biosynthesis of nepetalactol or nepetalactone stereoisomers, as a versatile system for the production of the iridoid natural product scaffold.

    • Néstor J. Hernández Lozada
    • Benke Hong
    • Sarah E. O’Connor
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Cardenolides such as digoxin from foxglove (Digitalis spp.) have been used to treat congenital heart conditions, cancer and other chronic diseases for decades. Here, authors report CYP87A enzymes that catalyse pregnenolone formation, the key entry point to the cardenolide pathway in plants.

    • Maritta Kunert
    • Chloe Langley
    • Prashant D. Sonawane
    ResearchOpen Access
    Nature Plants
    Volume: 9, P: 1607-1617