Nature Search

Publisher Correction: Exploitation of the Leishmania exosomal pathway by Leishmania RNA virus 1

Vanessa Diniz Atayde
Alonso da Silva Lira Filho
Martin Olivier
Amendments and Corrections26 Feb 2019
Nature Microbiology

Volume: 4, P: 724
Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E

The eukaryotic translation-initiation factor eIF4E is a rate-limiting factor in protein translation. Sonenberg and colleagues show that phosphorylation of eIF4E modulates the antiviral response by selectively stimulating translation of the NF-κB inhibitor IκBα

Barbara Herdy
Maritza Jaramillo
Nahum Sonenberg
Research29 Apr 2012
Nature Immunology

Volume: 13, P: 543-550
A randomized clinical trial of lipid metabolism modulation with fenofibrate for acute coronavirus disease 2019

Fenofibrate has been shown to inhibit SARS-CoV-2 replication in vitro. Results from a randomized clinical trial show that treating patients with COVID-19 with fenofibrate has no significant effect on clinically relevant outcomes.

Julio A. Chirinos
Patricio Lopez-Jaramillo
Pedro Antonio Segura-Saldaña
Research07 Nov 2022
Nature Metabolism

Volume: 4, P: 1847-1857
Cap-dependent translation initiation monitored in living cells

mRNA translation is tightly regulated to preserve cellular homeostasis. Here live-cell spectroscopy and single-particle tracking are combined to interrogate the binding dynamics of endogenous initiation factors to mRNAs 5’cap, revealing the sequence of translation initiation factors assembly and disassembly; and the clustering of translation in neurons.

Valentina Gandin
Brian P. English
Robert H. Singer
ResearchOpen Access02 Nov 2022
Nature Communications

Volume: 13, P: 1-15
Exploitation of the Leishmania exosomal pathway by Leishmania RNA virus 1

Leishmania exosomes function as viral envelopes for Leishmania RNA virus 1 (LRV1) and facilitate LRV1 transmission, resulting in more aggressive mucocutaneous disease triggered in response to the double-stranded RNA virus in the mammalian host.

Vanessa Diniz Atayde
Alonso da Silva Lira Filho
Martin Olivier
Research28 Jan 2019
Nature Microbiology

Volume: 4, P: 714-723
Translational control of the innate immune response through IRF-7

Production of type-I interferon is regulated by the transcription factor IRF-7. This paper shows that IRF-7 is negatively regulated by translational repressor proteins 4E-BP1 and 4E-BP2. Viral infection promotes mTOR-mediated phosphorylation of the repressor proteins and allows type-I interferon production to proceed.

Rodney Colina
Mauro Costa-Mattioli
Nahum Sonenberg
Research13 Feb 2008
Nature

Volume: 452, P: 323-328
Transcriptional profiling of macrophages reveals distinct parasite stage-driven signatures during early infection by Leishmania donovani

Visnu Chaparro
Tyson E. Graber
Maritza Jaramillo
ResearchOpen Access16 Apr 2022
Scientific Reports

Volume: 12, P: 1-13
Analysis of the Trichuris suis excretory/secretory proteins as a function of life cycle stage and their immunomodulatory properties

Louis-Philippe Leroux
Mohamad Nasr
Armando Jardim
ResearchOpen Access29 Oct 2018
Scientific Reports

Volume: 8, P: 1-17

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Publisher Correction: Exploitation of the Leishmania exosomal pathway by Leishmania RNA virus 1

Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E

A randomized clinical trial of lipid metabolism modulation with fenofibrate for acute coronavirus disease 2019

Cap-dependent translation initiation monitored in living cells

Exploitation of the Leishmania exosomal pathway by Leishmania RNA virus 1

Translational control of the innate immune response through IRF-7

Transcriptional profiling of macrophages reveals distinct parasite stage-driven signatures during early infection by Leishmania donovani

Analysis of the Trichuris suis excretory/secretory proteins as a function of life cycle stage and their immunomodulatory properties

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