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Showing 1–7 of 7 results
Advanced filters: Author: Marja Nieuwland Clear advanced filters

  • Tumour-reactive CD8+ T cells are enriched in functional clusters with tumour cells and/or antigen-presenting cells and can be isolated and expanded from clinical samples.

    • Sofía Ibáñez-Molero
    • Johanna Veldman
    • Daniel S. Peeper
    ResearchOpen Access
    Nature
    Volume: 649, P: 467-476

  • The presence of classical type 1 dendritic cells (cDC1) positively influences prognosis in cancer, but their intricate networking with the various T cell types found in the tumour microenvironment is not fully appreciated. Here the authors show that cDC1 encounter with CD4+ helper T-cells transforms their gene expression signature, and these “helped” dendritic cells enable the function of anti-tumour cytotoxic T-cells.

    • Xin Lei
    • Indu Khatri
    • Yanling Xiao
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • The origin of cancer-associated fibroblasts (CAFs) in cancer remains to be identified. Here, single-cell transcriptomics, in vivo and in vitro studies suggest that CD26+ and CD26- normal fibroblasts transform into distinct CAF subpopulations in mouse models of breast cancer.

    • Julia M. Houthuijzen
    • Roebi de Bruijn
    • Jos Jonkers
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-21

  • Anthracycline-based drugs can kill cancer cells by inhibiting topoisomerase II and promoting DNA double-strand breaks. Pang et al. show that anthracyclines also induce eviction of histones from open chromatin regions and, in doing so, modulate DNA repair and apoptosis in human cancer cells.

    • Baoxu Pang
    • Xiaohang Qiao
    • Jacques Neefjes
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-13

  • Loss of REV7 is shown to regulate end resection of double-stranded DNA breaks in BRCA1-deficient cells, leading to PARP inhibitor resistance and restoration of homologous recombination; REV7 dictates pathway choice in BRCA1-deficient cells and during immunoglobulin class switching.

    • Guotai Xu
    • J. Ross Chapman
    • Sven Rottenberg
    Research
    Nature
    Volume: 521, P: 541-544

  • The lack of robust and high-throughput technologies to analyze the human TCR repertoire has been a bottleneck in the analysis of human T cell responses. Linnemann and colleagues have addressed this issue by using a TCR gene capture technology that, because of its quantitative nature, allows the rapid identification of TCRab pairs from bulk populations of cells without the need for single-cell cloning. Such an approach should be useful in obtaining defined antigen-reactive TCRs for therapeutic purposes.

    • Carsten Linnemann
    • Bianca Heemskerk
    • Ton N M Schumacher
    Research
    Nature Medicine
    Volume: 19, P: 1534-1541