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Showing 1–3 of 3 results
Advanced filters: Author: Marjan Biocanin Clear advanced filters

  • This study introduces single-cell transcription factor (TF) sequencing, a single-cell barcoded and doxycycline-inducible TF overexpression approach that reveals dose-sensitive functional classes of TFs and cellular heterogeneity by mapping TF dose-dependent transcriptomic changes during the reprogramming of mouse embryonic multipotent stromal cells.

    • Wangjie Liu
    • Wouter Saelens
    • Bart Deplancke
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 2522-2535

  • Lymph nodes in various locations of the body differ in their cell composition and gene expression signatures. Here authors show that the rapid postnatal expansion of lymph nodes is governed by CD34 + stromal cells and fibroblastic reticular stromal cell progenitors, distinguished by intrinsic, microbiome-independent core epigenetic blueprints.

    • Joern Pezoldt
    • Carolin Wiechers
    • Jochen Huehn
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19