Nature Search

HIV-1 recombinant poxvirus vaccine induces cross-protection against HIV-2 challenge in rhesus macaques

Alash'le G. Abimiku
Genoveffa Franchini
Marjorie Robert-Guroff
Research01 Apr 1995
Nature Medicine

Volume: 1, P: 321-329
Long-term protection of chimpanzees against high-dose HIV-1 challenge induced by immunization

Michael D. Lubeck
Robert Natuk
Marjorie Robert-Guroff
Research01 Jun 1997
Nature Medicine

Volume: 3, P: 651-658
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Herpes simplex virus ophthalmia

Marjorie A Monnickendam
Reviews01 Jan 1988
Eye

Volume: 2, P: S56-S69
Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children

Multisystem inflammatory syndrome in children (MIS-C) onsets in COVID-19 patients with manifestations similar to Kawasaki disease (KD). Here the author probe the peripheral blood transcriptome of MIS-C patients to find signatures related to natural killer (NK) cell activation and CD8+ T cell exhaustion that are shared with KD patients.

Noam D. Beckmann
Phillip H. Comella
Alexander W. Charney
ResearchOpen Access11 Aug 2021
Nature Communications

Volume: 12, P: 1-15
The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells

NKp46 recognizes externalized calreticulin, which translocates from the ER to the cell membrane during ER stress, indicating a danger-associated molecular pattern that eliminates ER-stressed cells.

Sumit Sen Santara
Dian-Jang Lee
Judy Lieberman
Research05 Apr 2023
Nature

Volume: 616, P: 348-356
Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

Paul Pharoah and colleagues report the results of a large genome-wide association study of ovarian cancer. They identify new susceptibility loci for different epithelial ovarian cancer histotypes and use integrated analyses of genes and regulatory features at each locus to predict candidate susceptibility genes, including OBFC1.

Catherine M Phelan
Karoline B Kuchenbaecker
Paul D P Pharoah
Research27 Mar 2017
Nature Genetics

Volume: 49, P: 680-691
Comprehensive genomic characterization of head and neck squamous cell carcinomas

The Cancer Genome Atlas presents an integrative genome-wide analysis of genetic alterations in 279 head and neck squamous cell carcinomas (HNSCCs), which are classified by human papillomavirus (HPV) status; alterations in EGFR, FGFR, PIK3CA and cyclin-dependent kinases are shown to represent candidate targets for therapeutic intervention in most HNSCCs.

Michael S. Lawrence
Carrie Sougnez
Wendell G. Yarbrough
ResearchOpen Access28 Jan 2015
Nature

Volume: 517, P: 576-582
Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae

Transcriptomic analyses of acute phase whole blood from a large cohort of patients with COVID-19 identify molecular determinants of post-infection long-term sequelae.

Ryan C. Thompson
Nicole W. Simons
Noam D. Beckmann
ResearchOpen Access08 Dec 2022
Nature Medicine

Volume: 29, P: 236-246
SARS-CoV-2 viral load is associated with increased disease severity and mortality

In this study, Massachusetts Consortium for Pathogen Readiness (MassCPR) investigators assess the relationship between SARS-CoV-2 viral load and COVID-19 disease severity and report that the levels of detectable viral RNA, especially in plasma, correlates with severity of respiratory disease, inflammatory markers and predicted risk of death.

Jesse Fajnzylber
James Regan
Alex Zhu
ResearchOpen Access30 Oct 2020
Nature Communications

Volume: 11, P: 1-9
Failure of Oxysterols Such as Lanosterol to Restore Lens Clarity from Cataracts

Damian M. Daszynski
Puttur Santhoshkumar
Peter F. Kador
ResearchOpen Access11 Jun 2019
Scientific Reports

Volume: 9, P: 1-14
Author Correction: Sampling the host response to SARS-CoV-2 in hospitals under siege

Alexander W. Charney
Nicole W. Simons
Miriam Merad
Amendments and Corrections05 Feb 2021
Nature Medicine

Volume: 27, P: 560
Author Correction: Sampling the host response to SARS-CoV-2 in hospitals under siege

Alexander W. Charney
Nicole W. Simons
Miriam Merad
Amendments and Corrections21 Aug 2020
Nature Medicine

Volume: 26, P: 1493
The mucosal immune system: master regulator of bidirectional gut–brain communications

Bidirectional gut–brain communications are proving key to both gastrointestinal and neurological diseases. This Review explores the role of the mucosal immune system as gatekeeper and master regulator of these brain–gut and gut–brain communications.

Nick Powell
Marjorie M. Walker
Nicholas J. Talley
Reviews18 Jan 2017
Nature Reviews Gastroenterology & Hepatology

Volume: 14, P: 143-159
Gastrointestinal eosinophils in health, disease and functional disorders

Eosinophils are potent innate immune cells that are numerous in the gastrointestinal tract in health and disease. This Review discusses the role of eosinophils in the pathogenesis of numerous disorders of the gastrointestinal tract, including primary eosinophilic gastrointestinal disorders, common functional conditions (such as dyspepsia), and gastrointestinal disorders in patients with allergic disease.

Nicholas Powell
Marjorie M. Walker
Nicholas J. Talley
Reviews02 Feb 2010
Nature Reviews Gastroenterology & Hepatology

Volume: 7, P: 146-156
An alternative role of F_oF₁-ATP synthase in Escherichia coli: synthesis of thiamine triphosphate

Tiziana Gigliobianco
Marjorie Gangolf
Lucien Bettendorff
ResearchOpen Access15 Jan 2013
Scientific Reports

Volume: 3, P: 1-7
Sampling the host response to SARS-CoV-2 in hospitals under siege

Alexander W. Charney
Nicole W. Simons
Miriam Merad
Correspondence27 Jul 2020
Nature Medicine

Volume: 26, P: 1157-1158
The intercellular adhesion molecule, cadherin-10, is a marker for human prostate luminal epithelial cells that is not expressed in prostate cancer

Marjorie M Walker
Sebastien M Ellis
Peter Clark
Research14 Dec 2007
Modern Pathology

Volume: 21, P: 85-95
Histopathologic findings associated with APOL1 risk variants in chronic kidney disease

Christopher P Larsen
Marjorie L Beggs
Barry I Freedman
Research01 Aug 2014
Modern Pathology

Volume: 28, P: 95-102
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Richard Houlston and colleagues report a genome-wide association study for colorectal cancer. They report three loci newly associated with colorectal cancer, bringing the total number of common susceptibility loci to 20.

Malcolm G Dunlop
Sara E Dobbins
Richard S Houlston
Research27 May 2012
Nature Genetics

Volume: 44, P: 770-776
The neurotrophic tyrosine kinase receptor TrkA and its ligand NGF are increased in squamous cell carcinomas of the lung

Fangfang Gao
Nathan Griffin
Hubert Hondermarck
ResearchOpen Access25 May 2018
Scientific Reports

Volume: 8, P: 1-11

Search

HIV-1 recombinant poxvirus vaccine induces cross-protection against HIV-2 challenge in rhesus macaques

Long-term protection of chimpanzees against high-dose HIV-1 challenge induced by immunization

Mapping the human genetic architecture of COVID-19

Herpes simplex virus ophthalmia

Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children

The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

Comprehensive genomic characterization of head and neck squamous cell carcinomas

Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae

SARS-CoV-2 viral load is associated with increased disease severity and mortality

Failure of Oxysterols Such as Lanosterol to Restore Lens Clarity from Cataracts

Author Correction: Sampling the host response to SARS-CoV-2 in hospitals under siege

Author Correction: Sampling the host response to SARS-CoV-2 in hospitals under siege

The mucosal immune system: master regulator of bidirectional gut–brain communications

Gastrointestinal eosinophils in health, disease and functional disorders

An alternative role of F_oF₁-ATP synthase in Escherichia coli: synthesis of thiamine triphosphate

Sampling the host response to SARS-CoV-2 in hospitals under siege

The intercellular adhesion molecule, cadherin-10, is a marker for human prostate luminal epithelial cells that is not expressed in prostate cancer

Histopathologic findings associated with APOL1 risk variants in chronic kidney disease

Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

The neurotrophic tyrosine kinase receptor TrkA and its ligand NGF are increased in squamous cell carcinomas of the lung

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