Nature Search

A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

Wei Jiao
Gurnit Atwal
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Communications

Volume: 11, P: 1-12
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Erratum: Innovations in image-guided radiotherapy

Dirk Verellen
Mark De Ridder
Guy Storme
Amendments and Corrections06 Dec 2007
Nature Reviews Cancer

Volume: 8, P: 71
Burdens of type 2 diabetes and cardiovascular disease attributable to sugar-sweetened beverages in 184 countries

Estimates from the Global Dietary Database indicated that 2.2 million new type 2 diabetes and 1.2 million new cardiovascular disease cases were attributable to sugar-sweetened beverages worldwide in 2020, with the highest burdens in sub-Saharan Africa, Latin America and the Caribbean.

Laura Lara-Castor
Meghan O’Hearn
Rubina Hakeem
ResearchOpen Access06 Jan 2025
Nature Medicine

Volume: 31, P: 552-564
Repositioning of the global epicentre of non-optimal cholesterol

From 1980 to 2018, the levels of total and non-high-density lipoprotein cholesterol increased in low- and middle-income countries, especially in east and southeast Asia, and decreased in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe.

Cristina Taddei
Bin Zhou
Majid Ezzati
ResearchOpen Access03 Jun 2020
Nature

Volume: 582, P: 73-77
Correction: Corrigendum: Stromal contribution to the colorectal cancer transcriptome

Claudio Isella
Andrea Terrasi
Enzo Medico
Amendments and Corrections28 Sept 2016
Nature Genetics

Volume: 48, P: 1296
Author Correction: A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

Wei Jiao
Gurnit Atwal
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Patent foramen ovale and cerebrovascular diseases

In this Review, Amish Desai, Cindy Fuller, Jill Jesurum and Mark Reisman discuss the possible link between patent foramen ovale and cryptogenic stroke, treatment options for prevention of paradoxical embolism related to patent foramen ovale and the controversial association between patent foramen ovale and migraine headaches.

Amish J Desai
Cindy J Fuller
Mark Reisman
Reviews01 Aug 2006
Nature Clinical Practice Cardiovascular Medicine

Volume: 3, P: 446-455
Enhancer hubs and loop collisions identified from single-allele topologies

Multi-contact 4C (MC-4C) sequencing analyzes multi-way conformations of individual alleles. MC-4C identifies the β-globin superenhancer as a hub that can accommodate two genes simultaneously and shows that CTCF-anchored loops collide in WAPL-depleted cells.

Amin Allahyar
Carlo Vermeulen
Wouter de Laat
Research09 Jul 2018
Nature Genetics

Volume: 50, P: 1151-1160
Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Contrary to the view that urbanization is a major driver of the global rise in obesity, the global increase in body-mass index is shown to be mostly due to increases in the body-mass indexes of rural populations.

Honor Bixby
James Bentham
Majid Ezzati
ResearchOpen Access08 May 2019
Nature

Volume: 569, P: 260-264
Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target

In this study, Vande Voorde et al. investigate the potential of untargeted metabolomics as a stratification tool for colorectal cancer (CRC). They present a comprehensive pipeline to uncover metabolic vulnerabilities in CRC based on its genetic origin. With this approach, they show perturbations in methionine metabolism linked to APC deficiency, and identify adenosylhomocysteinase as an actionable therapeutic target.

Johan Vande Voorde
Rory T. Steven
Owen J. Sansom
ResearchOpen Access14 Aug 2023
Nature Metabolism

Volume: 5, P: 1303-1318
Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis

Douglas Winton and colleagues report the results of a large insertional mutagenesis screen to identify drivers of intestinal tumorigenesis in mice. The study identifies a large number of potential cancer drivers, including new modifiers of canonical Wnt signaling and components of the FGF pathway.

H Nikki March
Alistair G Rust
David J Adams
Research06 Nov 2011
Nature Genetics

Volume: 43, P: 1202-1209
Author Correction: Burdens of type 2 diabetes and cardiovascular disease attributable to sugar-sweetened beverages in 184 countries

Laura Lara-Castor
Meghan O’Hearn
Rubina Hakeem
Amendments and CorrectionsOpen Access28 Jan 2025
Nature Medicine

Volume: 31, P: 696
Innovations in image-guided radiotherapy

How can image-guided radiotherapy be used to optimize radiotherapy doses to the tumour while sparing sensitive surrounding healthy tissue?

Dirk Verellen
Mark De Ridder
Guy Storme
Reviews01 Dec 2007
Nature Reviews Cancer

Volume: 7, P: 949-960
A safety and feasibility randomized placebo controlled trial exploring electroencephalographic effective connectivity neurofeedback treatment for fibromyalgia

Lucy Anderson
Dirk De Ridder
Divya Bharatkumar Adhia
ResearchOpen Access02 Jan 2025
Scientific Reports

Volume: 15, P: 1-15
The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

An in vivo transposon screen in a pancreatic cancer model identifies frequent inactivation of Usp9x; deletion of Usp9x cooperates with Kras^G12D to accelerate rapidly pancreatic tumorigenesis in mice, validating their genetic interaction.

Pedro A. Pérez-Mancera
Alistair G. Rust
David A. Tuveson
Research29 Apr 2012
Nature

Volume: 486, P: 266-270
NF-κB inhibition impairs the radioresponse of hypoxic EMT-6 tumour cells through downregulation of inducible nitric oxide synthase

M De Ridder
D L Van den Berge
G A Storme
ResearchOpen Access28 Jan 2003
British Journal of Cancer

Volume: 88, P: 120-124
Production of a Recombinant Bovine Enterokinase Catalytic Subunit in the Methylotrophic Yeast Pichia pastoris

Laura A. Vozza
Leonard Wittwer
James P. Hoeffler
Research01 Jan 1996
Bio/Technology

Volume: 14, P: 77-81
Stromal contribution to the colorectal cancer transcriptome

Claudio Isella and colleagues report an analysis of colorectal cancer (CRC) gene expression data from patient-derived xenografts, which they use to reconcile three commonly used CRC classification systems. They find that the stem/serrated/mesenchymal (SSM) transcriptional subtype of CRC, previously linked to poor prognosis, is driven by stromal cells rather than tumor cells.

Claudio Isella
Andrea Terrasi
Enzo Medico
Research23 Feb 2015
Nature Genetics

Volume: 47, P: 312-319
Gini's mean difference and the long-term prognostic value of nodal quanta classes after pre-operative chemotherapy in advanced breast cancer

Vincent Vinh-Hung
Hilde Van Parijs
Mark De Ridder
ResearchOpen Access22 Feb 2022
Scientific Reports

Volume: 12, P: 1-11
Reovirus mutant jin-3 exhibits lytic and immune-stimulatory effects in preclinical human prostate cancer models

Arjanneke F. van de Merbel
Geertje van der Horst
Gabri van der Pluijm
ResearchOpen Access16 Jun 2021
Cancer Gene Therapy

Volume: 29, P: 793-802
Exploring electroencephalographic infraslow neurofeedback treatment for chronic low back pain: a double-blinded safety and feasibility randomized placebo-controlled trial

Divya Bharatkumar Adhia
Ramakrishnan Mani
Dirk De Ridder
ResearchOpen Access20 Jan 2023
Scientific Reports

Volume: 13, P: 1-17
A randomised, double-blind, placebo-controlled parallel trial of closed-loop infraslow brain training in food addiction

Sook Ling Leong
Sven Vanneste
Dirk De Ridder
ResearchOpen Access03 Aug 2018
Scientific Reports

Volume: 8, P: 1-9
The acute effects on duodenal gene expression in healthy men following consumption of a low-fat meal enriched with theobromine or fat

Lotte Smolders
Ronald P. Mensink
Jogchum Plat
ResearchOpen Access26 Jan 2018
Scientific Reports

Volume: 8, P: 1-11

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