Here, Mark Tarnopolsky and colleagues propose that the systemic benefits of exercise are mediated by exosomes containing peptides and nucleic acids (exerkines) that act in an autocrine, paracrine and/or endocrine manner. They also discuss the therapeutic potential of using exerkine-enriched native or modified exosomes to treat metabolic diseases such as obesity and type 2 diabetes mellitus.
- Adeel Safdar
- Ayesha Saleem
- Mark A. Tarnopolsky
