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Showing 1–2 of 2 results
Advanced filters: Author: Mark J. Calcott Clear advanced filters

  • Efforts to rationally engineer nonribosomal peptide synthetase (NRPS) enzymes have focused on making individual modifications. Here the authors describe a targeted random engineering approach that uses thousands of NRPS domains amplified from the soil metagenome for mass substitution experiments.

    • Sarah R. Messenger
    • Edward M. R. McGuinniety
    • Mark J. Calcott
    Research
    Nature Chemical Biology
    Volume: 20, P: 251-260

  • Non-ribosomal peptide synthases are multimodular enzymes comprised of adenylation (A), condensation (C) and thiolation domains. Here, the authors show that non-ribosomal peptides can be generated solely by A domain substitutions, providing evidence that the postulated substrate specifying role of C-domains may be rare in nature.

    • Mark J. Calcott
    • Jeremy G. Owen
    • David F. Ackerley
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10