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Showing 1–5 of 5 results
Advanced filters: Author: Mark Leuchtenberger Clear advanced filters

  • Many cities and countries still view the foundation of a biotech sector as desirable for a high-tech, intellectually driven economy. But a discussion by seasoned biotech management and investors suggests that attaining an environment with the right mix of money, management and innovation remains a difficult and long-term challenge.

    • Fritz Bühler
    • C. Mark Tang
    • Pedro de Noronha Pissarra
    Comments & Opinion
    Bioentrepreneur
    P: 1-3

  • The genetic basis of metabolic diseases is incompletely understood. Here, by high-throughput phenotyping of 2,016 knockout mouse strains, Rozman and colleagues identify candidate metabolic genes, many of which are associated with unexplored regulatory gene networks and metabolic traits in human GWAS.

    • Jan Rozman
    • Birgit Rathkolb
    • Martin Hrabe de Angelis
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16

  • Systemic dissection of sexually dimorphic phenotypes in mice is lacking. Here, Karp and the International Mouse Phenotype Consortium show that approximately 10% of qualitative traits and 56% of quantitative traits in mice as measured in laboratory setting are sexually dimorphic.

    • Natasha A. Karp
    • Jeremy Mason
    • Jacqueline K. White
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • The full extent of the genetic basis for hearing impairment is unknown. Here, as part of the International Mouse Phenotyping Consortium, the authors perform a hearing loss screen in 3006 mouse knockout strains and identify 52 new candidate genes for genetic hearing loss.

    • Michael R. Bowl
    • Michelle M. Simon
    • Steve D. M. Brown
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11