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Showing 1–5 of 5 results
Advanced filters: Author: Mark McCleland Clear advanced filters

  • PD-L1 immune checkpoint inhibition has been used for several tumour types. Here, the authors use immunohistochemistry, tumour mutation burden and RNA-seq data from 366 patients with different indications to identify molecular signatures of response to atezolizumab and reveal pathway heterogeneity and the involvement of non-immune pathways.

    • Romain Banchereau
    • Ning Leng
    • Thomas Powles
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • The genetic basis of gastric cancer, the fourth most common cancer worldwide, remains poorly understood. Here, the authors sequence and analyse the exomes and transcriptomes of primary gastric tumours and cell lines, and identify a ZAK kinase isoform that may have an oncogenic role in gastric cancer.

    • Jinfeng Liu
    • Mark McCleland
    • Zemin Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-8

  • The application of a potent lactate dehydrogenase (LDHA) inhibitor GNE-140 on pancreatic cancer cells revealed that resistance to GNE-140 is attributable to an AMPK–mTOR–S6K-mediated switch in utilization from glycolysis to oxidative phosphorylation.

    • Aaron Boudreau
    • Hans E Purkey
    • Thomas O'Brien
    Research
    Nature Chemical Biology
    Volume: 12, P: 779-786

  • The development of selective ubiquitin-specific protease-7 (USP7) inhibitors GNE-6640 and GNE-6776, which induce tumour cell death and reveal differential kinetics of Lys-48 and Lys-63-linked ubiquitin chain depolymerization by USP7.

    • Lorna Kategaya
    • Paola Di Lello
    • Ingrid E. Wertz
    Research
    Nature
    Volume: 550, P: 534-538