Nature Search

Stabilization of protein structure by interaction of α-helix dipole with a charged side chain

Das̆a S˘ali
Mark Bycroft
Alan R. Fersht
Research20 Oct 1988
Nature

Volume: 335, P: 740-743
Bardet–Biedl syndrome is linked to DNA markers on chromosome 11 q and is genetically heterogeneous

Mark Leppert
Lisa Baird
Richard Alan Lewis
Research01 May 1994
Nature Genetics

Volume: 7, P: 108-112
The role of gastropod pedal mucus in locomotion

Mark Denny
Research15 May 1980
Nature

Volume: 285, P: 160-161
Primary structural studies of the Qa-2 alloantigen: implications for the evolution of the MHC

Mark J. Soloski
Jonathan W. Uhr
Ellen S. Vitetta
Research22 Apr 1982
Nature

Volume: 296, P: 759-761
Long-term health outcomes in adolescents with obesity treated with faecal microbiota transplantation: 4-year follow-up

In this 4-year unblinded follow-up study, the authors evaluate 63% of the participants of a double-blind randomised control trial that assessed the effects of faecal microbiota transplantation (FMT) on adolescents with obesity.

Brooke C. Wilson
Michele Zuppi
Brooke Wilson
ResearchOpen Access28 Aug 2025
Nature Communications

Volume: 16, P: 1-11
Human dopamine D₁ receptor encoded by an intronless gene on chromosome 5

Roger K. Sunahara
Hyman B. Niznik
Brian F. O'Dowd
Research06 Sept 1990
Nature

Volume: 347, P: 80-83
Osteohistology of a Triassic dinosaur population reveals highly variable growth trajectories typified early dinosaur ontogeny

Daniel E. Barta
Christopher T. Griffin
Mark A. Norell
ResearchOpen Access15 Oct 2022
Scientific Reports

Volume: 12, P: 1-14
Vascular system defects and neuronal apoptosis in mice lacking Ras GTPase-activating protein

Mark Henkemeyer
Derrick J. Rossi
Tony Pawson
Research26 Oct 1995
Nature

Volume: 377, P: 695-701
Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder

Genome-wide analyses identify 30 independent loci associated with obsessive–compulsive disorder, highlighting genetic overlap with other psychiatric disorders and implicating putative effector genes and cell types contributing to its etiology.

Nora I. Strom
Zachary F. Gerring
Manuel Mattheisen
ResearchOpen Access13 May 2025
Nature Genetics

Volume: 57, P: 1389-1401
Antibodies against AIDS proteins

YAIR DEVASH
KEVIN REAGAN
C. YONG KANG
Research14 Jun 1990
Nature

Volume: 345, P: 581
SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade

mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.

Adam J. Grippin
Christiano Marconi
Steven H. Lin
ResearchOpen Access22 Oct 2025
Nature

Volume: 647, P: 488-497
Identification of HIV transmitting CD11c⁺ human epidermal dendritic cells

Composition and function of immune populations at barrier surfaces is crucial for response to infection. Here, the authors identify a population of dendritic cells in human epidermis, abundant in anogenital epithelia and distinct from Langerhans cells by surface phenotype and by high capacity for HIV infection and transmission.

Kirstie M. Bertram
Rachel A. Botting
Andrew N. Harman
ResearchOpen Access21 Jun 2019
Nature Communications

Volume: 10, P: 1-15
Detectable clonal mosaicism and its relationship to aging and cancer

Luis Pérez-Jurado, Stephen Chanock and colleagues detect clonal chromosomal abnormalities in peripheral blood or buccal samples from individuals in the general population. They show that the frequency of such events increases with age and is associated with elevated risk of developing subsequent hematological cancers.

Kevin B Jacobs
Meredith Yeager
Stephen J Chanock
Research06 May 2012
Nature Genetics

Volume: 44, P: 651-658
Electron transfer reagent binding sites on plastocyanin

David J. Cookson
Mark T. Hayes
Peter E. Wright
Research14 Feb 1980
Nature

Volume: 283, P: 682-683
Sustained survival of human hepatocytes in mice: A model for in vivo infection with human hepatitis B and hepatitis delta viruses

Kazuo Ohashi
Patricia L. Marion
Mark A. Kay
Research01 Mar 2000
Nature Medicine

Volume: 6, P: 327-331
Persistence of episomal HIV-1 infection intermediates in patients on highly active anti-retroviral therapy

Mark E. Sharkey
Ian Teo
Mario Stevenson
Research01 Jan 2000
Nature Medicine

Volume: 6, P: 76-81
New human gene encoding a positive modulator of HIV Tat-mediated transactivation

Hiroshi Shibuya
Kenji Irie
Kunihiro Matsumoto
Research25 Jun 1992
Nature

Volume: 357, P: 700-702
Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry

A genome-wide association study of age at onset of walking in over 70,000 infants found 11 significant loci. Age at onset of walking showed SNP heritability of 24%, a reliable polygenic score and genetic overlap with ADHD and brain phenotypes.

Anna Gui
Anja Hollowell
Angelica Ronald
ResearchOpen Access07 May 2025
Nature Human Behaviour

Volume: 9, P: 1470-1487
Antigen persistence and TLR stimulation contribute to induction of a durable HIV-1-specific neutralizing antibody response

Vaccination efficiency in HIV infection is hampered by the low immunogenicity of HIV-1 Env glycoprotein (Env). Here authors optimise the neutralising antibody response to Env by stabilizing the Env trimers in the context of expressing them in a Newcastle Disease Virus-like particle and providing conditions that mimics replicating virus infection.

Kenta Matsuda
Mitra Harrison
Mark Connors
ResearchOpen Access03 Jun 2025
Nature Communications

Volume: 16, P: 1-17
CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus

Li Wu
Roland Scollay
Ken Shortman
Research03 Jan 1991
Nature

Volume: 349, P: 71-74
Altered glucose-6-phosphate dehydrogenase in bromodeoxyuridine-substituted cells

MICHAEL D. BICK
MARK SOFFER
Research01 Apr 1976
Nature

Volume: 260, P: 788-791
Nitrogen transport by vertically migrating diatom mats in the North Pacific Ocean

Tracy A. Villareal
Mark A. Altabet
Karen Culver-Rymsza
Research24 Jun 1993
Nature

Volume: 363, P: 709-712
HIV induces thymus depletion in vivo

Mark L. Bonyhadi
Linda Rabin
Hideto Kaneshima
Research24 Jun 1993
Nature

Volume: 363, P: 728-732
A novel serine esterase expressed by cytotoxic T lymphocytes

Mark S. Pasternack
Herman N. Eisen
Research25 Apr 1985
Nature

Volume: 314, P: 743-745
RNA structure probing reveals the structural basis of Dicer binding and cleavage

Sequencing methods such as icSHAPE were developed to probe RNA structures transcriptome-wide in cells. To probe intact RNA structures, the authors develop icSHAPE-MaP and apply to Dicer-bound substrates showing that distance measuring is important for Dicer cleavage of pre-miRNAs.

Qing-Jun Luo
Jinsong Zhang
Qiangfeng Cliff Zhang
ResearchOpen Access07 Jun 2021
Nature Communications

Volume: 12, P: 1-12
APOBEC3 proteins mediate the clearance of foreign DNA from human cells

APOBEC3 cytidine deaminases have been implicated in restriction of retroviruses and retrotransposons in mammalian cells. Now human APOBEC3A is shown to be upregulated by interferon and to catalyze the deamination of foreign double-stranded DNA transfected into primary cells or cell lines, with no detectable effect on genomic DNA.

Mark D Stenglein
Michael B Burns
Reuben S Harris
Research10 Jan 2010
Nature Structural & Molecular Biology

Volume: 17, P: 222-229
Small-molecule inhibition of HIV-1 Vif

The HIV-1 protein Vif, which promotes degradation of the host cell's antiviral APOBEC3 proteins, has yet to be targeted for therapeutic intervention. Nathans et al. use a high-throughput fluorescence screen to identify a small molecule that inhibits HIV replication in cultured cells by antagonizing Vif in an APOBEC3-dependent manner.

Robin Nathans
Hong Cao
Tariq M Rana
Research21 Sept 2008
Nature Biotechnology

Volume: 26, P: 1187-1192
RNA interference–induced hepatotoxicity results from loss of the first synthesized isoform of microRNA-122 in mice

Mark Kay and colleagues report that liver toxicity due to high doses of shRNAs is triggered by a decrease in an isoform of the abundant liver microRNA, miR-122.

Paul N Valdmanis
Shuo Gu
Mark A Kay
Research11 Apr 2016
Nature Medicine

Volume: 22, P: 557-562
A hot-Jupiter progenitor on a super-eccentric retrograde orbit

The spectroscopic and photometric observations of a high-mass, transiting warm Jupiter, TIC 241249530 b, with an orbital eccentricity of 0.94, provide evidence that hot Jupiters may have formed by means of a high-eccentricity tidal-migration pathway.

Arvind F. Gupta
Sarah C. Millholland
Carl Ziegler
ResearchOpen Access17 Jul 2024
Nature

Volume: 632, P: 50-54
Mapping a gene for combined hyperlipidaemia in a mutant mouse strain

Lawrence W. Castellani
Ari Weinreb
Aldons J. Lusis
Research01 Apr 1998
Nature Genetics

Volume: 18, P: 374-377
The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes

Phagocytic cells of the innate immune system play critical roles in defence against invading pathogens including the opportunistic pathogen Candida albicans. Here the authors show that C. albicans derived Candidalysin in addition to being a cell-damaging toxin to mononuclear phagocytes is a trigger of NLRP3 inflammasome activation in these cells.

Lydia Kasper
Annika König
Bernhard Hube
ResearchOpen Access15 Oct 2018
Nature Communications

Volume: 9, P: 1-20
Separation of uncertainty and interindividual variability in human exposure modeling

Ad M J Ragas
Femke P E Brouwer
Mark A J Huijbregts
Research09 Apr 2008
Journal of Exposure Science & Environmental Epidemiology

Volume: 19, P: 201-212
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

A meta-analysis of genome-wide association studies across different populations highlights new risk loci and provides a genetic risk score that can stratify prostate cancer risk across ancestries.

David V. Conti
Burcu F. Darst
Christopher A. Haiman
Research04 Jan 2021
Nature Genetics

Volume: 53, P: 65-75
A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus

Robert R Graham
Sergey V Kozyrev
Marta E Alarcón-Riquelme
Research16 Apr 2006
Nature Genetics

Volume: 38, P: 550-555
Identification of a major co-receptor for primary isolates of HIV-1

HongKui Deng
Rong Liu
Nathaniel R. Landau
Research20 Jun 1996
Nature

Volume: 381, P: 661-666
The trans-activator gene of HTLV-III is essential for virus replication

Amanda G. Fisher
Mark B. Feinberg
Flossie Wong-Staal
Research27 Mar 1986
Nature

Volume: 320, P: 367-371
Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

A multi-ancestry genome-wide association study of prostate cancer performed in 156,319 cases and 788,443 controls identifies 187 novel risk variants associated with the disease. Genetic risk scores associated with overall risk, and risk of aggressive disease in men of African ancestry.

Anqi Wang
Jiayi Shen
Christopher A. Haiman
Research09 Nov 2023
Nature Genetics

Volume: 55, P: 2065-2074
Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

It is unclear how often genetic mosaicism of chromosome X arises. Here, the authors examine women with cancer and cancer-free controls and show that X chromosome mosaicism occurs more frequently than on autosomes, especially on the inactive X chromosome, but is not linked to non-haematologic cancer risk

Mitchell J. Machiela
Weiyin Zhou
Stephen J. Chanock
ResearchOpen Access13 Jun 2016
Nature Communications

Volume: 7, P: 1-9
Mutations in the HPV16 genome induced by APOBEC3 are associated with viral clearance

The APOBEC mutational signature is prevalent in different tumour types. Here, using HPV16- positive cervical samples, the authors show that the signature is more prevalent in the viral genome of benign or clearing HPV16 infections compared to the viral genomes of the more advanced precancerous lesions or cervical cancer.

Bin Zhu
Yanzi Xiao
Lisa Mirabello
ResearchOpen Access14 Feb 2020
Nature Communications

Volume: 11, P: 1-12
p53 promotes revival stem cells in the regenerating intestine after severe radiation injury

The tumor suppressor p53 is the guardian of the genome. Here, the authors use comprehensive approaches to demonstrate that transient p53 activity induces revival stem cells to promote the regeneration of severely irradiated intestinal epithelium in mice.

Clara Morral
Arshad Ayyaz
David G. Kirsch
ResearchOpen Access08 Apr 2024
Nature Communications

Volume: 15, P: 1-14
Confirmation and refutation of very luminous galaxies in the early Universe

JWST spectroscopy confirms redshifts for two very luminous galaxies with z > 11, and also demonstrates that another candidate with suggested z ≈ 16 instead has z = 4.9.

Pablo Arrabal Haro
Mark Dickinson
Jorge A. Zavala
Research14 Aug 2023
Nature

Volume: 622, P: 707-711
A mesoscale phytoplankton bloom in the polar Southern Ocean stimulated by iron fertilization

Philip W. Boyd
Andrew J. Watson
John Zeldis
Research12 Oct 2000
Nature

Volume: 407, P: 695-702
Germline BRCA2 6174delT mutations in Ashkenazi Jewish pancreatic cancer patients

Hilmi Özcelik
Beverly Schmocker
Mark Redston
Correspondence01 May 1997
Nature Genetics

Volume: 16, P: 17-18
Performance enhancement and degradation mechanism identification of a single-atom Co–N–C catalyst for proton exchange membrane fuel cells

Platinum-group-metal-free, non-iron catalysts are highly desirable for the oxygen reduction reaction at proton exchange membrane (PEM) fuel cell cathodes, as they avoid the detrimental Fenton reactions. Now, a cobalt and nitrogen co-doped carbon catalyst with atomically dispersed porphyrin-like CoN₄C₁₂ sites is reported with an improved activity and durability in PEM fuel cell conditions.

Xiaohong Xie
Cheng He
Yuyan Shao
Research30 Nov 2020
Nature Catalysis

Volume: 3, P: 1044-1054
Regional brain morphology and current antidepressant use: findings from 32 international cohorts from the ENIGMA major depressive disorder working group

Chaira Serrarens
Yara J. Toenders
Laura S. van Velzen
ResearchOpen Access03 Nov 2025
Molecular Psychiatry

Volume: 30, P: 5625-5636
Mammalian plasma membranes

Mark S. Bretscher
Martin C. Raff
Reviews06 Nov 1975
Nature

Volume: 258, P: 43-49
Machine learning for diagnosis of myocardial infarction using cardiac troponin concentrations

A clinical decision support system for diagnosis of myocardial infarction, based on machine learning models that use a single measurement of high-sensitivity troponin, outperforms clinical guidelines that use fixed cardiac troponin thresholds for diagnosis.

Dimitrios Doudesis
Kuan Ken Lee
Stephen W. Smith
ResearchOpen Access11 May 2023
Nature Medicine

Volume: 29, P: 1201-1210
Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium

Laura S. van Velzen
Lejla Colic
Lianne Schmaal
ResearchOpen Access24 Oct 2025
Translational Psychiatry

Volume: 15, P: 1-11
Phospholipase Cγ activates Ras on the Golgi apparatus by means of RasGRP1

Trever G. Bivona
Ignacio Pérez de Castro
Mark R. Philips
Research29 Jun 2003
Nature

Volume: 424, P: 694-698
Clinical utility of a serum biomarker panel in distinguishing prostate cancer from benign prostate hyperplasia

Michael A. Kiebish
Poornima Tekumalla
Niven R. Narain
ResearchOpen Access23 Jul 2021
Scientific Reports

Volume: 11, P: 1-9

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