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Showing 1–4 of 4 results
Advanced filters: Author: Mark Stegall Clear advanced filters

  • Much progress has been made in understanding the processes underlying antibody-mediated rejection (AMR) of transplanted organs. In this Review, the authors discuss the role of the complement system in acute and chronic AMR, with specific emphasis on renal transplantation, and describe studies demonstrating that blockade of terminal complement activation can prevent AMR in sensitized renal transplant recipients.

    • Mark D. Stegall
    • Marcio F. Chedid
    • Lynn D. Cornell
    Reviews
    Nature Reviews Nephrology
    Volume: 8, P: 670-678

  • Finding a suitable donor kidney for renal transplant candidates who are allosensitized to human leukocyte antigen (HLA) can be challenging. In this Review, Gloor and Stegall discuss currently available strategies for screening and desensitization and new techniques that are under development. Treatments that target donor-specific antibodies have shown some success in reversing acute antibody-mediated rejection, a common complication in antibody-incompatible kidney transplantation. New treatments, such as anti-C5 antibody-mediated complement blockade and proteasome inhibitor-mediated plasma cell depletion, are promising therapeutic avenues.

    • James Gloor
    • Mark D. Stegall
    Reviews
    Nature Reviews Nephrology
    Volume: 6, P: 297-306

  • Despite being recommended, day-zero biopsies are often not performed, due to the cost and time. Here, the authors show that machine learning and donor’s basic parameters can predict the biopsy, offering a reliable virtual estimation of the day-zero biopsy findings.

    • Daniel Yoo
    • Gillian Divard
    • Alexandre Loupy
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • Regulatory B cells have been shown to play critical roles in the modulation of the immune system. Here, the authors implicate TIGIT expression in B cells with the process of immuno-regulation.

    • Md Mahmudul Hasan
    • Sumi Sukumaran Nair
    • SangKon Oh
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15