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Showing 1–11 of 11 results
Advanced filters: Author: Mark Tozer Clear advanced filters

  • Head and neck squamous cell carcinoma (HNSCC) frequency and risk factors vary considerably across regions and ancestries. Here, the authors conduct a multi-ancestry genome-wide association study and fine mapping study of HNSCC subsites in cohorts from multiple continents, finding susceptibility and protective loci, gene-environment interactions, and gene variants related to immune response.

    • Elmira Ebrahimi
    • Apiwat Sangphukieo
    • Tom Dudding
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Data collected from more than 2,000 taxa provide an unparalleled opportunity to quantify how extreme wildfires affect biodiversity, revealing that the largest effects on plants and animals were in areas with frequent or recent past fires and within extensively burnt areas.

    • Don A. Driscoll
    • Kristina J. Macdonald
    • Ryan D. Phillips
    ResearchOpen Access
    Nature
    Volume: 635, P: 898-905

  • Similarities in cancers can be studied to interrogate their etiology. Here, the authors use genome-wide association study summary statistics from six cancer types based on 296,215 cases and 301,319 controls of European ancestry, showing that solid tumours arising from different tissues share a degree of common germline genetic basis.

    • Xia Jiang
    • Hilary K. Finucane
    • Sara Lindström
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-23

  • The International Union for Conservation of Nature’s Global Ecosystem Typology has been developed to provide a systematic framework for data on all of Earth’s ecosystems in a unified theoretical context to support biodiversity conservation and ecosystem services.

    • David A. Keith
    • José R. Ferrer-Paris
    • Richard T. Kingsford
    ResearchOpen Access
    Nature
    Volume: 610, P: 513-518

  • Head and neck squamous cell carcinoma can occur with and without the presence of HPV infection. Here, the authors utilise Mendelian randomization to assess the causal effects of smoking and alcohol on HPV-positive and HPV-negative head and neck cancer development.

    • Abhinav Thakral
    • John JW. Lee
    • Osvaldo Espin-Garcia
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-9

  • Imaging biomarkers (IBs) are used extensively in drug development and cancer research, but important differences exist between IBs and biospecimen-derived biomarkers. A tailored 'roadmap' is required for the development of new IBs to be used either in clinical research or for decision-making in healthcare. In this Consensus statement, a group of experts assembled by CRUK and the EORTC present 14 key recommendations for accelerating the clinical translation of IBs.

    • James P. B. O'Connor
    • Eric O. Aboagye
    • John C. Waterton
    ReviewsOpen Access
    Nature Reviews Clinical Oncology
    Volume: 14, P: 169-186

  • The SDGs and CitiesIPCC offer an unprecedented opportunity for urban transformation, but bold, integrated action to address the constraints imposed by economic, cultural and political dynamics is needed. We move beyond a narrow, technocentric view and identify five key knowledge pathways to catalyse urban transformation.

    • Patricia Romero-Lankao
    • Harriet Bulkeley
    • Debashish Munshi
    Comments & Opinion
    Nature Climate Change
    Volume: 8, P: 754-756