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Selective pressures of platinum compounds shape the evolution of therapy-related myeloid neoplasms

The mechanisms behind therapy-related myeloid neoplasms (t-MN) occurring after chemotherapy treatment remain poorly understood, particularly for paediatric patients. Here, the authors analyse t-MN in children using single-cell genomics, showing how t-MN founding cells can expand after cessation of therapy and how the platinum-induced growth inhibition is TP53-dependent.

Eline J. M. Bertrums
Jurrian K. de Kanter
Ruben van Boxtel
ResearchOpen Access17 Jul 2024
Nature Communications

Volume: 15, P: 1-16
White blood cell and cell-free DNA analyses for detection of residual disease in gastric cancer

Identifying patients that will respond to a particular therapy remains a key challenge in precision oncology. Here, in gastric cancer, the authors show that circulating tumour DNA can predict recurrence, provided that the signal from white blood cells is filtered out.

Alessandro Leal
Nicole C. T. van Grieken
Victor E. Velculescu
ResearchOpen Access27 Jan 2020
Nature Communications

Volume: 11, P: 1-11
Genomic landscape of metastatic colorectal cancer

Response to drug therapy in colorectal cancer (CRC) patients has been associated with tumour heterogeneity. Here the authors analyse DNA copy number aberrations in primary tumours from CRC patients and identify genetic variants that influence drug response.

Josien C. Haan
Mariette Labots
Gerrit A. Meijer
ResearchOpen Access14 Nov 2014
Nature Communications

Volume: 5, P: 1-12
Distribution and functional impact of DNA copy number variation in the rat

Victor Guryev
Kathrin Saar
Edwin Cuppen
Research28 Apr 2008
Nature Genetics

Volume: 40, P: 538-545
Bacteriophage ISP eliminates Staphylococcus aureus in planktonic phase, but not in the various stages of the biofilm cycle

Mariëlle Verheul
Aat A. Mulder
Peter H. Nibbering
ResearchOpen Access22 Jun 2024
Scientific Reports

Volume: 14, P: 1-11
Mutation accumulation and developmental lineages in normal and Down syndrome human fetal haematopoiesis

Karlijn A. L. Hasaart
Freek Manders
Ruben van Boxtel
ResearchOpen Access31 Jul 2020
Scientific Reports

Volume: 10, P: 1-14
A first-in-man phase 1 study of the DNA-dependent protein kinase inhibitor peposertib (formerly M3814) in patients with advanced solid tumours

Mark T. J. van Bussel
Ahmad Awada
Jan H. M. Schellens
ResearchOpen Access24 Nov 2020
British Journal of Cancer

Volume: 124, P: 728-735
Improving the identification of frail elderly newly diagnosed multiple myeloma patients

Claudia A. M. Stege
Kazem Nasserinejad
Sonja Zweegman
Research15 Feb 2021
Leukemia

Volume: 35, P: 2715-2719

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Selective pressures of platinum compounds shape the evolution of therapy-related myeloid neoplasms

White blood cell and cell-free DNA analyses for detection of residual disease in gastric cancer

Genomic landscape of metastatic colorectal cancer

Distribution and functional impact of DNA copy number variation in the rat

Bacteriophage ISP eliminates Staphylococcus aureus in planktonic phase, but not in the various stages of the biofilm cycle

Mutation accumulation and developmental lineages in normal and Down syndrome human fetal haematopoiesis

A first-in-man phase 1 study of the DNA-dependent protein kinase inhibitor peposertib (formerly M3814) in patients with advanced solid tumours

Improving the identification of frail elderly newly diagnosed multiple myeloma patients

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