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Showing 1–13 of 13 results
Advanced filters: Author: Mark W. Tibbitt Clear advanced filters

  • This study reports on self-aggregating injectable microcrystals for administering long-acting drug implants via low-profile needles, a key factor in patient adoption. Microcrystal self-aggregation is engineered through a solvent exchange process to form depots with minimal polymer excipient, demonstrating enhanced long-term release of a model contraceptive drug in rodents.

    • Vivian R. Feig
    • Sanghyun Park
    • Giovanni Traverso
    ResearchOpen Access
    Nature Chemical Engineering
    Volume: 2, P: 209-219

  • Natural ecosystems efficiently sequester CO2, but containing and controlling living systems remains challenging. Here, the authors engineer a photosynthetic living material for dual CO2 sequestration via biomass accumulation and microbially-induced calcium carbonate precipitation.

    • Dalia Dranseike
    • Yifan Cui
    • Mark W. Tibbitt
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Mouldable hydrogels find a variety of applications in the biomedical industry. Here, Appel et al. show a method to fabricate hydrogels through a self-assembly process based on the interaction between biopolymers and functional nanoparticles for multistage drug delivery in vivo.

    • Eric A. Appel
    • Mark W. Tibbitt
    • Robert Langer
    Research
    Nature Communications
    Volume: 6, P: 1-9

  • Integrating cell-laden hydrogels effectively into the 3D printing process is a challenge in the creation of tissue engineering scaffolds. Here, the authors describe an additive manufacturing technique to combine polymer and cell-containing networks with 3D-printed mechanical supports.

    • Héloïse Ragelle
    • Mark W. Tibbitt
    • Robert Langer
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • Mechanical cues from the local cellular microenvironment can direct cell fate. Now, experiments with human mesenchymal stem cells cultured on phototunable soft poly(ethylene glycol) hydrogels show that the cells remember past physical environments—with the transcriptional co-activators YAP and TAZ acting as a mechanical rheostat—and therefore that appropriate doses of mechanical cues can be used to manipulate the cells’ fate.

    • Chun Yang
    • Mark W. Tibbitt
    • Kristi S. Anseth
    Research
    Nature Materials
    Volume: 13, P: 645-652

  • Ding et al. find a mechanism coordinating fatty acid and glucose supply. Glucose-driven Golgi phosphatidylinositol 4-phosphate levels impact the assembly of E3 ligase complex CUL7–FBXW8, controlling adipose triglyceride lipase levels and lipolysis.

    • Lianggong Ding
    • Florian Huwyler
    • Christian Wolfrum
    ResearchOpen Access
    Nature Cell Biology
    Volume: 26, P: 552-566

  • In this Perspective article, Huwyler, Binz and colleagues discuss the future of long-term normothermic machine perfusion for livers and propose a staged assessment approach for ex situ perfused organs.

    • Florian Huwyler
    • Jonas Binz
    • Pierre-Alain Clavien
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 22, P: 721-733

  • Biomaterial structures can be printed with near-infrared light within the tissues of living animals by using photosensitive polymer hydrogels.

    • Mark W. Tibbitt
    News & Views
    Nature Biomedical Engineering
    Volume: 4, P: 851-852

  • Polymer materials that can reorganize over time or under specific conditions have enormous advantages over static polymer networks. This Review discusses the many classes of molecular bonding motifs used to introduce dynamicity to polymer materials and outlines the design rules for engineering the interaction timescales for desired applications.

    • Matthew J. Webber
    • Mark W. Tibbitt
    Reviews
    Nature Reviews Materials
    Volume: 7, P: 541-556