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Showing 1–3 of 3 results
Advanced filters: Author: Mark Walkenhorst Clear advanced filters

  • Here the authors show that endogenous or therapeutically delivered GDF-15 activates brainstem neurons that trigger splenic β-adrenergic signaling. This, in turn, suppresses autoreactive T cells and reduces neuroinflammation, identifying a possible target for multiple sclerosis treatment.

    • Jana K. Sonner
    • Audrey Kahn
    • Manuel A. Friese
    ResearchOpen Access
    Nature Immunology
    P: 1-13

  • Mucosal associated invariant T (MAIT) cells reside in barrier organs, but their contribution to inflammatory processes in the kidneys is not fully known. Here authors find by single cell RNA sequencing that among the different MAIT cell subtypes found at steady state, a population with MAIT17 signature is expanded in both human crescentic glomerulonephritis and its mouse model, and these cells may play protective role in the disease.

    • Ann-Christin Gnirck
    • Marie-Sophie Philipp
    • Jan-Eric Turner
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Mucosal-associated invariant T (MAIT) cells mediate protection from pathogens, but their role in autoimmunity is unclear. Here the authors show that, in a mouse experimental autoimmune encephalomyelitis model, MAIT cells accumulate in the inflamed central nervous system and serve protective functions when activated via their T cell receptor.

    • Mark Walkenhorst
    • Jana K. Sonner
    • Anne Willing
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16