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Showing 1–3 of 3 results
Advanced filters: Author: Markia A. Smith Clear advanced filters

  • Jeffrey Damrauer, Markia Smith et al. used existing datasets from cholangiocarcinoma (CCA) and hepatocellular carcinoma (HCC) to characterize two subsets of HCC distinct from prototypical HCC tumors, based on comprehensive analysis of molecular data. The two classes differed from HCC by their copy number, gene expression and mutational signature and exhibited worse progression free survival, highlighting the need to identify class-specific biomarkers and develop targeted therapies for these forms of cancer.

    • Jeffrey S. Damrauer
    • Markia A. Smith
    • Katherine A. Hoadley
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-13

  • It’s time for a paradigm shift in the scientific enterprise. Our social responsibilities, especially as stakeholders in a field such as genetics, are central to the responsible conduct of research.

    • Daphne Oluwaseun Martschenko
    • Markia Smith
    Comments & Opinion
    Nature Genetics
    Volume: 53, P: 255-256

  • Perou and colleagues perform genomic, transcriptomic and epigenetic analyses on pairs of primary and metastatic breast tumors, detecting subtype switching and changes in immune signatures and DNA methylation patterns associated with metastasis.

    • Susana Garcia-Recio
    • Toshinori Hinoue
    • Charles M. Perou
    ResearchOpen Access
    Nature Cancer
    Volume: 4, P: 128-147