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Showing 1–4 of 4 results
Advanced filters: Author: Marko Kaksonen Clear advanced filters

  • Clathrin-mediated endocytosis is the main mechanism for internalization of cell-surface molecules and surface-bound cargoes. Although the machineries that drive the formation of endocytic vesicle are intricate, an understanding of endocytosis is being unravelled at the molecular level.

    • Marko Kaksonen
    • Aurélien Roux
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 19, P: 313-326

  • Adapter proteins assist clathrin coated pit assembly. Here, the authors combine native mass spectrometry, crystallography and SAXS measurements and show that the membrane–proximal domains of the adaptor proteins epsin and Sla2 form complexes mediated through phosphatidylinositol 4,5-bisphosphate interfaces leading to assembly formation.

    • Maria M. Garcia-Alai
    • Johannes Heidemann
    • Rob Meijers
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • Polymerizing actin seems to provide the force for deforming and moving membranes at different steps of the endocytic pathway. Live-cell imaging is shedding light on the order and timing of the molecular events and mechanisms of actin function during endocytosis.

    • Marko Kaksonen
    • Christopher P. Toret
    • David G. Drubin
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 7, P: 404-414