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Showing 1–4 of 4 results
Advanced filters: Author: Markus D. Solbach Clear advanced filters
  • The molecular mechanisms underlying drug resistance in relapsed or refractory (rr) acute myeloid leukemia (AML) remain to be explored. Here, the use of bulk and single cell multi-omics and ex vivo drug profiling for 21 rrAML patients reveals mechanisms of resistance to the Bcl-2 inhibitor venetoclax and treatment vulnerabilities.

    • Rebekka Wegmann
    • Ximena Bonilla
    • Alexandre P. A. Theocharides
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18
  • In the Tumor Profiler proof-of-concept observational study, a multiomics approach for profiling tumors from patients with melanoma was feasible, returning data within 4 weeks and informing treatment recommendations in 75% of cases.

    • Nicola Miglino
    • Nora C. Toussaint
    • Andreas Wicki
    ResearchOpen Access
    Nature Medicine
    Volume: 31, P: 2430-2441
  • Research on biodiversity–ecosystem functioning relationships tends to focus on single trophic groups. This analysis of two biodiversity experiments, representing forests and grasslands, shows that plant diversity promotes ecosystem multifunctionality not only directly, but also by enhancing the diversity of other trophic levels.

    • Yi Li
    • Andreas Schuldt
    • Xiaojuan Liu
    Research
    Nature Ecology & Evolution
    Volume: 8, P: 2037-2047