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Showing 1–10 of 10 results
Advanced filters: Author: Markus Koglin Clear advanced filters

  • In this study, authors employ fragment-based lead discovery to identify WRN inhibitors. The fragment hits reveal an additional allosteric pocket and uncover a previously uncharacterized structural conformation of the WRN helicase domain with unique orientations of the ATPase domains

    • Rachel L. Palte
    • Mihir Mandal
    • Daniel F. Wyss
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-17

  • The X-ray crystal structure of the transmembrane portion of the human glucagon receptor, a class B G-protein-coupled receptor (GPCR), is solved in the presence of the antagonist MK-0893, with potential implications for the development of therapeutics that target other class B GPCRs.

    • Ali Jazayeri
    • Andrew S. Doré
    • Fiona H. Marshall
    Research
    Nature
    Volume: 533, P: 274-277

  • Serial femtosecond X-ray crystallography permits the use of very small protein crystals; however, a continuous flow of sample is required. Weierstall et al. design and demonstrate an injector system that can supply microcrystals in the lipidic cubic phase, dramatically reducing the quantities of protein required.

    • Uwe Weierstall
    • Daniel James
    • Vadim Cherezov
    Research
    Nature Communications
    Volume: 5, P: 1-6

  • G protein-coupled receptors (GPCRs) are key drug targets. In this article, Marshall and colleagues discuss the progress made towards generating GPCR-targeting antibodies, including which antigen formats and antibody platforms have been most successful. They review the current pipeline and outline outstanding challenges in antibody generation.

    • Catherine J. Hutchings
    • Markus Koglin
    • Fiona H. Marshall
    Reviews
    Nature Reviews Drug Discovery
    Volume: 16, P: 787-810

  • Crystal lattice disorder, which gives rise to a continuous diffraction pattern, is exploited to determine the structure of the integral membrane protein complex photosystem II to a higher resolution than could be achieved using Bragg diffraction alone.

    • Kartik Ayyer
    • Oleksandr M. Yefanov
    • Henry N. Chapman
    Research
    Nature
    Volume: 530, P: 202-206