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Showing 1–10 of 10 results
Advanced filters: Author: Markus T. Bohnsack Clear advanced filters

  • RNA modifications are key regulators of RNA functions. Here, the authors identify METTL8 as the enzyme installing m3C32 in mitochondrial tRNAThr/Ser(UCN). Lack of these modifications affects tRNA structure and impairs mitochondrial translation.

    • Nicole Kleiber
    • Nicolas Lemus-Diaz
    • Markus T. Bohnsack
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19

  • The DNA helicase ASCC3 is the largest subunit of the activating signal co-integrator complex (ASCC), and its DNA unwinding activity is required for the AlkBH3/ASCC-dependent DNA de-alkylation repair pathway. Here, the authors identify a minimal stable complex of the two ASCC subunits ASCC2 and ASCC3, determine the complex crystal structure and further show that cancer-related mutations at the interface between both proteins reduce ASCC2–ASCC3 affinity.

    • Junqiao Jia
    • Eva Absmeier
    • Markus C. Wahl
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • Early steps of large 60S ribosomal subunit biogenesis are not well understood. Here, the authors combine biochemical experiments with protein-RNA crosslinking and mass spectrometry to show that the RNA helicase Dbp7 is key player during early 60S ribosomal assembly. Dbp7 regulates a series of events driving compaction of domain V/VI in early pre60S ribosomal particles.

    • Gerald Ryan R. Aquino
    • Philipp Hackert
    • Markus T. Bohnsack
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • The molecular events underlying the assembly and maturation of the early pre-60S particles during eukaryotic ribosome synthesis are not well understood. Here, the authors combine yeast genetics and biochemical experiments to characterise the functions of two important players of eukaryotic ribosome biogenesis, the box C/D snoRNP snR190 and the helicase Dbp7, which both interact. They show that the snR190 snoRNA acts as a RNA chaperone that assists the structuring of the 25S rRNA during the maturation of early pre-60S particles and that Dbp7 is important for facilitating remodeling events in the peptidyl transferase center region of the 25S rRNAs during the maturation of early pre-60S particles.

    • Mariam Jaafar
    • Julia Contreras
    • Anthony K. Henras
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Group B streptococci (GBS) started causing serious infections in newborn babies in the 1960s. Here, the authors show that the emergence of GBS diseases was associated with worldwide dissemination of a few clones that were resistant to tetracycline, an antibiotic that became widely used in the 1950s.

    • Violette Da Cunha
    • Mark R. Davies
    • Philippe Glaser
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-12

  • Pre-ribosomes undergo numerous structural rearrangements during their assembly. Here the authors identify the binding sites of three essential RNA helicases on pre-ribosomal particles, enabling them to provide insights into the structural and compositional changes that occur during biogenesis of the large ribosomal subunit.

    • Lukas Brüning
    • Philipp Hackert
    • Markus T. Bohnsack
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • All aspects of gene regulation involve RNA helicases, which bind or remodel RNA and RNA–protein complexes. Recent data establish a link between helicase structure, mechanism of function and biological roles, including in diseases such as cancer and neurological disorders, with implications for the design of small-molecule inhibitors.

    • Katherine E. Bohnsack
    • Soon Yi
    • Markus T. Bohnsack
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 24, P: 749-769