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Showing 1–14 of 14 results
Advanced filters: Author: Markus Weingarth Clear advanced filters

  • In this Review, Weingarth and colleagues discuss both recently discovered compounds and established envelope-targeting antibiotics, including compounds that target Gram-positive bacteria, more complex Gram-negative bacteria and mycobacterial pathogens, with a particular focus on their drug–target interactions.

    • Charalampos Ntallis
    • Nathaniel I. Martin
    • Markus Weingarth
    Reviews
    Nature Reviews Microbiology
    P: 1-14

  • An integrated structural biology approach encompassing solid-state NMR and molecular dynamics simulations was implemented to obtain an atomic view of the ordered polyglutamine core and fuzzy coat of the amyloid-like protein aggregates implicated in Huntington’s disease.

    • Mahdi Bagherpoor Helabad
    • Irina Matlahov
    • Markus S. Miettinen
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Constriction of the selectivity filter is assumed to be a hallmark of C-type inactivation in K+ channels. Using different high-resolution methods, this study shows a distinct C-type inactivation mechanism in a KcsA mutant that emulates Kv-channels.

    • Ahmed Rohaim
    • Bram J. A. Vermeulen
    • Markus Weingarth
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • The natural antibiotic teixobactin kills bacteria by direct binding to their cognate cell wall precursors (Lipid II and III). Here authors use solid-state NMR to reveal the native binding mode of teixobactins and show that teixobactins only weakly bind to Lipid II in anionic cellular membranes.

    • Rhythm Shukla
    • João Medeiros-Silva
    • Markus Weingarth
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Spontaneous activity shifts at constant experimental conditions are widespread among ion channels but the molecular origins are poorly understood. Here, using solid-state NMR and MD simulations, the authors reveal that modal gating shifts in K + channels are caused by large shifts in the channel dynamics which perturb the selectivity filter.

    • Shehrazade Jekhmane
    • João Medeiros-Silva
    • Markus Weingarth
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Antibiotics that target the peptidoglycan precursor lipid II are promising templates for next-generation antibiotics. Here authors use solid-state NMR and monitor lipid II-binding antibiotics, such as nisin, directly in cell membranes.

    • João Medeiros-Silva
    • Shehrazade Jekhmane
    • Markus Weingarth
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • Processing bodies are membrane less organelles that contain enzymes involved in mRNA turnover, among them enhancer of decapping 3 (Edc3). Here the authors use solid- and solution-state NMR spectroscopy to characterize the structural organization and dynamics of Edc3 and find that its interactions with RNA and between the different Edc3 domains are largely preserved in the phase-separated state.

    • Reinier Damman
    • Stefan Schütz
    • Marc Baldus
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • The β-barrel assembly machinery (BAM) catalyzes β-barrel protein insertion into the outer membrane of E.coli. Here authors employ high-sensitivity solid-state NMR to reveal how the lipid environment and formation of the BamA-BamCDE complex affect BamA structure and dynamics with regards to the lateral gate and the β-barrel associated domains.

    • Cecilia Pinto
    • Deni Mance
    • Marc Baldus
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • Self-assembling peptides have broad biomedical relevance, but the relationship between molecular properties of monomers, intermediates and the supramolecular assembly process remains somewhat elusive. Here, studies of fibril-forming surfactant-like peptides with different β-sheet propensities and charged residues show that the amount of formed peptide nanofibers is defined by oligomeric nucleation propensities.

    • Chun Yin Jerry Lau
    • Federico Fontana
    • Enrico Mastrobattista
    ResearchOpen Access
    Communications Chemistry
    Volume: 3, P: 1-10

  • This Review examines the diverse strategies utilized by naturally occurring antibiotics and suggests how they have provided, and will in future provide, inspiration for the design of novel antibiotics.

    • Kim Lewis
    • Richard E. Lee
    • Ingo Wohlgemuth
    Reviews
    Nature
    Volume: 632, P: 39-49