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Showing 1–3 of 3 results

Advanced filters: Author: Marla J. Giddins Clear advanced filters

Combinatorial protein engineering identifies potent CRISPR activators with reduced toxicity

CRISPR activators are powerful tools for controlling gene expression, but they suffer from inconsistent efficacy and high toxicity. Here, authors develop a high-throughput method to test thousands of CRISPR activators, revealing distinct principles of activator biology and delivering improved tools.

Marla Giddins
Alexander F. Kratz
Alejandro Chavez
ResearchOpen Access20 Nov 2025
Nature Communications

Volume: 16, P: 1-21
Fecal exfoliome sequencing captures immune dynamics of the healthy and inflamed gut

Profiling host RNA shed in feces reveals disease states in the gut.

Yiming Huang
Yiwei Sun
Harris H. Wang
Research17 Nov 2025
Nature Biotechnology

P: 1-11
Colonizing multidrug-resistant bacteria and the longitudinal evolution of the intestinal microbiome after liver transplantation

In a large prospective cohort of liver transplantation (LT) recipients, the authors identify associations between colonization by multidrug-resistant bacteria (MDRB) and microbiome dysbiosis pre- and post-LT, suggesting colonizing MDRB as an important target for microbiome-informed therapeutic approaches post-LT.

Medini K. Annavajhala
Angela Gomez-Simmonds
Anne-Catrin Uhlemann
ResearchOpen Access17 Oct 2019
Nature Communications

Volume: 10, P: 1-12

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